Synthesis of New Combretastatin A-4 Analogues and Study of Their Anti-Inflammatory Activity

Synthesis of New Combretastatin A-4 Analogues and Study of Their Anti-Inflammatory Activity Full article

Journal

Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620

Output data

Year: 2015, Volume: 41, Number: 1, Pages: 70-76 Pages count : DOI: 10.1134/S1068162015010033

Tags

combretastatin A-4; alpha-acetylenic ketones; beta-vinylamines; anti-inflammatory activity; vasoactive properties

Authors

Davydova M. P. ¹ , Sorokina I. V. ² , Tolstikova T. G. ² , Mamatyuk V. I. ^2,3 , Fadeev D. S. ² , Vasilevsky S. F. ^2,3

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Voevodsky Inst Chem Kinet & Combust, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
3	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

A new approach to the synthesis of natural combretastatin A-4 analogues based on the interaction of a- acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) was proposed. Previously unknown analogues of combretastatin A-4 containing the 13-aminovinylcarbonyl bridges were synthesized. Anti-inflammatory activity of the obtained compounds was studied on models of exudative inflammation caused by histamine or concanavalin A.

Davydova M.P. , Sorokina I.V. , Tolstikova T.G. , Mamatyuk V.I. , Fadeev D.S. , Vasilevsky S.F.
Synthesis of New Combretastatin A-4 Analogues and Study of Their Anti-Inflammatory Activity
Russian Journal of Bioorganic Chemistry. 2015. V.41. N1. P.70-76. DOI: 10.1134/S1068162015010033 WOS Scopus РИНЦ

Давыдова М.П. , Сорокина И.В. , Толстикова Т.Г. , Маматюк В.И. , Фадеев Д.С. , Василевский С.Ф.
Синтез новых аналогов комбретастатина а-4 и изучение их противовоспалительной активности
Биоорганическая химия (RUSS J BIOORG CHEM+). 2015. Т.41. №1. С.82. РИНЦ

Published print:	Jan 1, 2015
Published online:	Jan 22, 2015

Web of science	WOS:000351574700010
Scopus	2-s2.0-84921653565
Elibrary	23968896
OpenAlex	W2038966470