Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells

Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells Full article

Journal

Bioorganic and Medicinal Chemistry
ISSN: 0968-0896 , E-ISSN: 1464-3391

Output data

Year: 2014, Volume: 22, Number: 1, Pages: 585-593 Pages count : DOI: 10.1016/j.bmc.2013.10.049

Tags

Glycyrrhetinic acid derivatives; Cytotoxicity; Nitric oxide; Biological activity; Selectivity index

Authors

Salomatina Oksana V. ¹ , Markov Andrey V. ² , Logashenko Evgeniya B. ² , Korchagina Dina V. ¹ , Zenkova Marina A. ² , Salakhutdinov Nariman F. ¹ , Vlassov Valentin V. ² , Tolstikov Genrikh A. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia

Here we report the synthesis and biological activity of new semi-synthetic derivatives of naturally occurring glycyrrhetinic acid bearing a 2-cyano-3-oxo-1-en moiety in the A-ring and double bonds and carbonyl groups in the C, D and E rings. Bioassays using murine macrophage-like and tumor cells show that compound 4, which differs from Soloxolone methyl by the absence of a 9(11)-double bond in the C-ring, displays anti-inflammatory and inhibitory activities with respect to tumor cells with a high selectivity index value. (C) 2013 Elsevier Ltd. All rights reserved.

Salomatina O.V. , Markov A.V. , Logashenko E.B. , Korchagina D.V. , Zenkova M.A. , Salakhutdinov N.F. , Vlassov V.V. , Tolstikov G.A.
Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells
Bioorganic and Medicinal Chemistry. 2014. V.22. N1. P.585-593. DOI: 10.1016/j.bmc.2013.10.049 WOS Scopus РИНЦ

Published print:

Jan 1, 2014

Web of science	WOS:000329068400056
Scopus	2-s2.0-84891402001
Elibrary	21862240
OpenAlex	W1978453782