Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)-1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model

Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)-1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model Full article

Journal

Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X

Output data

Year: 2014, Volume: 11, Number: 5, Pages: 611-617 Pages count : 7 DOI: 10.2174/1570180811666131210000316

Tags

Neuroprotection; Parkinson disease; MPTP; Mice; Monoterpene; Carene; Vanillin

Authors

Pavlova Alla V. ¹ , Il'ina Irina V. ¹ , Morozova Ekaterina A. ¹ , Korchagina Dina V. ¹ , Kurbakova Svetlana Yu. ¹ , Sorokina Irina V. ¹ , Tolstikova Tatyana G. ¹ , Volcho Konstantin P. ¹ , Salakhutdinov Nariman F. ¹

Affiliations

1	N.N.Vorozhtsov Novosibirsk Institute of Organic Chemistry, Lavrentiev av., 9, 630090 Novosibirsk, Russian Federation

Studies of the neuroprotective activity of a series of monoterpene-derived compounds on the MPTP mice model showed that 4-[(3aR, 7aS)-1,3,3a, 4,5,7a-hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol 15 possessed a considerable neuroprotective activity. Compound 15 was synthesized by one-stage reaction of (+)-2-carene with vanillin. It has low acute toxicity and significantly decreased the development of catalepsy evoked by haloperidol in rats.

Pavlova A.V. , Il'ina I.V. , Morozova E.A. , Korchagina D.V. , Kurbakova S.Y. , Sorokina I.V. , Tolstikova T.G. , Volcho K.P. , Salakhutdinov N.F.
Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)-1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model
Letters in Drug Design and Discovery. 2014. V.11. N5. P.611-617. DOI: 10.2174/1570180811666131210000316 WOS Scopus РИНЦ

Published print:

Dec 9, 2013

Web of science	WOS:000335394500009
Scopus	2-s2.0-84899888576
Elibrary	21876919
OpenAlex	W2326172959