Use of the Mannich Reaction to Synthesize Spin-Labeled Derivatives of the Natural Flavonoid Dihydroquercetin

Use of the Mannich Reaction to Synthesize Spin-Labeled Derivatives of the Natural Flavonoid Dihydroquercetin Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2014, Volume: 50, Number: 2, Pages: 261-265 Pages count : DOI: 10.1007/s10600-014-0927-7

Tags

dihydroquercetin; nitroxyl radicals; spin-labeled compounds; Mannich reaction

Authors

Kosheleva N. V. ¹ , Chernyak E. I. ¹ , Polienko Yu F. ¹ , Morozov S. V. ¹ , Grigor'ev I. A. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia

Mono-substituted spin-labeled compounds were synthesized from Mannich reactions of dihydroquercetin with 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl, 3-amino-2,2,5,5-tetramethylpyrrolidine-1-oxyl, and 3-aminomethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl. According to preliminary data, the compounds possessed antioxidant activity and selective cytotoxicity against various tumor cells and were promising for biomedical tests including magnetic resonance tomography.

Kosheleva N.V. , Chernyak E.I. , Polienko Y.F. , Morozov S.V. , Grigor'ev I.A.
Use of the Mannich Reaction to Synthesize Spin-Labeled Derivatives of the Natural Flavonoid Dihydroquercetin
Chemistry of Natural Compounds. 2014. V.50. N2. P.261-265. DOI: 10.1007/s10600-014-0927-7 WOS Scopus РИНЦ

Published print:	May 1, 2014
Published online:	May 13, 2014

Web of science	WOS:000336800200014
Scopus	2-s2.0-84903160656
Elibrary	24061513
OpenAlex	W1993935343