Triglyceride-lowering agents | Sciact

Triglyceride-lowering agents Full article

Journal

Bioorganic and Medicinal Chemistry
ISSN: 0968-0896 , E-ISSN: 1464-3391

Output data

Year: 2014, Volume: 22, Number: 14, Pages: 3551-3564 Pages count : DOI: 10.1016/j.bmc.2014.05.008

Tags

Fibrates; Nicotinic acid; Omega-3 fatty acids; PPAR alpha and PPAR alpha/gamma agonists; Squalene synthase inhibitors; Statins; Triglyceride-lowering agents

Authors

Salakhutdinov Nariman F. ^1,2 , Laev Sergey S. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Div, Vorozhtsov Inst Organ Chem, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

This review is the first attempt at systematization of the literature data on the structures and activities of triglyceride-lowering agents which used in medical practice or are in development. The effects and mechanisms of action of statins, squalene synthase inhibitors, fibrates, PPAR alpha and PPAR alpha/gamma agonists, nicotinic acid, omega-3 fatty acids and some other molecular targets were considered. Unfortunately, to date, harmless and effective triglyceride-lowering drug still does not exist and there is still need for development of better triglyceride-lowering agents. (C) 2014 Elsevier Ltd. All rights reserved.

Salakhutdinov N.F. , Laev S.S.
Triglyceride-lowering agents
Bioorganic and Medicinal Chemistry. 2014. V.22. N14. P.3551-3564. DOI: 10.1016/j.bmc.2014.05.008 WOS Scopus РИНЦ

Published print:

Jul 1, 2014

Web of science	WOS:000337991100001
Scopus	2-s2.0-84902553960
Elibrary	24059959
OpenAlex	W2017565824