Studies of the Lipophilic Components of a Dense Extract of the Herb Alfredia Cernua and its Nootropic Properties

Studies of the Lipophilic Components of a Dense Extract of the Herb Alfredia Cernua and its Nootropic Properties Full article

Journal

Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031

Output data

Year: 2014, Volume: 48, Number: 3, Pages: 181-185 Pages count : DOI: 10.1007/s11094-014-1074-y

Tags

Alfredia cernua herb; dense extract; chromatomass spectrometric analysis; aliphatic acids; phenolcarboxylic acids; di- and triterpenoic acids; neutral lipophilic compounds; nootropic activity; T maze

Authors

Shilova I. V. ^1,2 , Kukina T. P. ^2,3 , Suslov N. I. ¹ , Sal'nikova O. I. ³ , Mustafin R. N. ¹

Affiliations

1	(Данные Web of science) Russian Acad Med Sci, Sci Res Inst Pharmacol, Siberian Branch, Tomsk, Russia
2	(Данные Web of science) Tomsk State Natl Res Univ, Tomsk, Russia
3	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk, Russia

Chromato-mass spectrometry (GC/MS) studies of the chemical composition of a dense extract of the herb Alfredia cernua (L.) Cass. prepared by processing raw material with 95 % ethanol identified 31 aliphatic, including 2-hydroxy- and dicarboxylic, acids, three phenolcarboxylic acids, one di- and two triterpenoic acids, and 16 neutral lipophilic components. A total of 40 compounds were detected in Alfredia cernua for the first time. T maze experiments showed that the plant extract promoted changes in the motivational domain in normal animals, activating appetitive and consumatory behavior due to nootropic and anxiolytic actions, which were greater than those of piracetam.

Shilova I.V. , Kukina T.P. , Suslov N.I. , Sal'nikova O.I. , Mustafin R.N.
Studies of the Lipophilic Components of a Dense Extract of the Herb Alfredia Cernua and its Nootropic Properties
Pharmaceutical Chemistry Journal. 2014. V.48. N3. P.181-185. DOI: 10.1007/s11094-014-1074-y WOS Scopus

Шилова И.В. , Кукина Т.П. , Суслов Н.И. , Сальникова О.И. , Мустафин Р.Н.
Изучение липофильных компонентов густого экстракта травы альфредии поникшей и его ноотропных свойств
Химико-фармацевтический журнал (PHARM CHEM J+). 2014. Т.48. №3. С.26-30. РИНЦ

Published print:	Jun 1, 2014
Published online:	Jul 22, 2014

Web of science	WOS:000340532100009
Scopus	2-s2.0-84905987432
OpenAlex	W2029173464