Dual Effects of Indoleamine 2,3-Dioxygenase Inhibitors on the Therapeutic Effects of Cyclophosphamide and Cycloplatam on Ehrlich Ascites Tumor in Mice

Dual Effects of Indoleamine 2,3-Dioxygenase Inhibitors on the Therapeutic Effects of Cyclophosphamide and Cycloplatam on Ehrlich Ascites Tumor in Mice Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2014, Volume: 157, Number: 4, Pages: 506-509 Pages count : DOI: 10.1007/s10517-014-2602-1

Tags

Ehrlich tumor; inhibitors of indoleamine 2,3-dioxygenase; cytostatic treatment

Authors

Bogdanova L. A. ¹ , Morozkova T. S. ¹ , Amitina S. A. ² , Mazhukin D. G. ² , Nikolin V. P. ³ , Popova N. A. ³ , Kaledin V. I. ³

Affiliations

1	(Данные Web of science) Russian Acad Med Sci, Res Inst Reg Pathol & Pathomorphol, Siberian Div, Novosibirsk, Russia
2	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Div, Novosibirsk, Russia
3	(Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Div, Novosibirsk 630090, Russia

Ethyl pyruvate, an inhibitor of indoleamine 2,3-dioxygenase, slightly suppressed the growth of transplantable Ehrlich tumor in mice and signifi cantly potentiated the therapeutic effect of cyclophosphamide. Another inhibitor amidoxime produced a similar effect. However, both ethyl pyruvate and amidoxime signifi cantly reduced the effect of cycloplatam therapy. The observed changes can be stipulated by different effects of cyclophosphamide and cycloplatam on the subpopulations of lymphoid cells taking part in the formation of antitumor immunity and resistance to tumors.

Bogdanova L.A. , Morozkova T.S. , Amitina S.A. , Mazhukin D.G. , Nikolin V.P. , Popova N.A. , Kaledin V.I.
Dual Effects of Indoleamine 2,3-Dioxygenase Inhibitors on the Therapeutic Effects of Cyclophosphamide and Cycloplatam on Ehrlich Ascites Tumor in Mice
Bulletin of Experimental Biology and Medicine. 2014. V.157. N4. P.506-509. DOI: 10.1007/s10517-014-2602-1 WOS Scopus РИНЦ

Богданова Л.А. , Морозкова Т.С. , Амитина С.А. , Мажукин Д.Г. , Николин В.П. , Попова Н.А. , Каледин В.И.
Двойственное влияние ингибиторов индоламин-2,3-диоксигеназы на терапевтическое действие циклофосфана и циклоплатама в отношении асцитной опухоли эрлиха у мышей
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2014. Т.157. №4. С.507-510. РИНЦ

Published print:	Aug 1, 2014
Published online:	Aug 12, 2014

Web of science	WOS:000340661000025
Scopus	2-s2.0-84927961791
Elibrary	24951899
OpenAlex	W2123374052