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Photogenerator of trichloroacetic acid as a promising detritylation agent for oligonucleotide microarray synthesis Full article

Journal Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620
Output data Year: 2014, Volume: 40, Number: 5, Pages: 586-588 Pages count : DOI: 10.1134/S1068162014050124
Tags photogenerated acids; trityl cation; oligodeoxyribonucleotides
Authors Sinyakov A. N. 1 , Nikolaenkova E. B. 2 , Os'kina I. A. 2 , Savel'ev V. A. 2 , Samsonov V. A. 2 , Tikhonov A. Y. 2 , Palatkina M. Yu. 3 , Zaytsev D. E. 3
Affiliations
1 (Данные Web of science) Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Novosibirsk 630090, Russia
2 (Данные Web of science) Russian Acad Sci, Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
3 (Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

Abstract: [[4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl]-2,2,2-trichloroacetate, which generates trichloroacetic acid when irradiated with light of 405 nm wavelength, has been studied as a detritylation agent in the oligonucleotide microarray synthesis. This agent was shown to be suitable for the deprotection of the 4,4'-dimethoxytrityl group during the solid phase oligonucleotide synthesis.
Cite: Sinyakov A.N. , Nikolaenkova E.B. , Os'kina I.A. , Savel'ev V.A. , Samsonov V.A. , Tikhonov A.Y. , Palatkina M.Y. , Zaytsev D.E.
Photogenerator of trichloroacetic acid as a promising detritylation agent for oligonucleotide microarray synthesis
Russian Journal of Bioorganic Chemistry. 2014. V.40. N5. P.586-588. DOI: 10.1134/S1068162014050124 WOS Scopus РИНЦ
ArticleLinkType.TRANSLATED_TO_ORIGINAL: Синяков А.Н. , Николаенкова Е.Б. , Оськина И.А. , Савельев В.А. , Самсонов В.А. , Тихонов А.Я. , Палаткина М.Ю. , Зайцев Д.Е.
Фотогенератор трихлоруксусной кислоты – перспективный детритилирующий агент для микрочипового олигонуклеотидного синтеза
Биоорганическая химия (RUSS J BIOORG CHEM+). 2014. Т.40. №5. С.636. DOI: 10.7868/S0132342314050121 Scopus РИНЦ
Dates:
Published print: Sep 1, 2014
Published online: Sep 12, 2014
Identifiers:
Web of science WOS:000342136800013
Scopus 2-s2.0-84920270869
Elibrary 24028675
OpenAlex W1981260779
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