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Monoterpene-containing substituted coumarins as inhibitors of respiratory syncytial virus (Rsv) replication Full article

Journal Molecules
, E-ISSN: 1420-3049
Output data Year: 2021, Volume: 26, Number: 24, Article number : 7493, Pages count : DOI: 10.3390/molecules26247493
Tags Antiviral activity; Coumarin; Cytotoxicity; F protein; Molecular modelling; Respiratory syncytial virus; Terpene
Authors Khomenko Tatyana M. 1 , Shtro Anna A. 2 , Galochkina Anastasia V. 2 , Nikolaeva Yulia V. 2 , Petukhova Galina D. 2 , Borisevich Sophia S. 3 , Korchagina Dina V. 1 , Volcho Konstantin P. 1 , Salakhutdinov Nariman F. 1
Affiliations
1 Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, Novosibirsk, 630090, Russian Federation
2 Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, St. Petersburg, 197376, Russian Federation
3 Laboratory of Physical Chemistry, Ufa Chemistry Institute of the Ufa Federal Research Center, 71 Octyabrya pr., Ufa, 450054, Russian Federation

Funding (1)

1 Российский Научный Фонд 21-13-00026

Abstract: Respiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for the first time, that O-linked coumarin–monoterpene conjugates are effective RSV inhibitors. The most potent compounds are active against both RSV serotypes, A and B. According to the results of the time-of-addition experiment, the conjugates act at the early stages of virus cycle. Based on molecular modelling data, RSV F protein may be considered as a possible target. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Cite: Khomenko T.M. , Shtro A.A. , Galochkina A.V. , Nikolaeva Y.V. , Petukhova G.D. , Borisevich S.S. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F.
Monoterpene-containing substituted coumarins as inhibitors of respiratory syncytial virus (Rsv) replication
Molecules. 2021. V.26. N24. 7493 . DOI: 10.3390/molecules26247493 WOS Scopus
Identifiers:
Web of science WOS:000736578200001
Scopus 2-s2.0-85121562211
OpenAlex W4200158185
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