Design, Synthesis, and Anti-Ulcer Activity of New 1-Thia-4,8-Diazaspiro[4,5]Decan-3-One Derivatives

Design, Synthesis, and Anti-Ulcer Activity of New 1-Thia-4,8-Diazaspiro[4,5]Decan-3-One Derivatives Full article

Journal

Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031

Output data

Year: 2022, Volume: 55, Number: 12, Pages: 1288-1292 Pages count : 5 DOI: 10.1007/s11094-022-02573-7

Tags

1-thia-4,8-diazaspiro[4,5]decan-3-ones; anti-ulcer activity; thiazolidin-4-one

Authors

Ivankin D.I. ¹ , Borisova M.S. ¹ , Sokolov D.N. ¹ , Luzina O.A. ¹ , Tolstikova T.G. ¹ , Salakhutdinov N.F. ¹

Affiliations

1	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090, Russian Federation

Aseries of compounds based on 1-thia-4,8-diazaspiro[4.5]decan-3-one was synthesized. Their activity as new anti-ulcer agents was investigated in vivo. 8-Benzyl-4-[3-(dimethylamino)propyl]-1-thia-4,8-diazaspiro-[4,5]decan-3-one, 8-benzyl-4-[2-(dimethylamino)ethyl]-1-thia-4,8-diazaspiro[4,5]decan-3-one, 4,8-dibenzyl-1-thia-4,8-diazaspiro[4,5]decan-3-one, and 8-benzyl-4-[3-(dibutylamino)propyl]-1-thia-4,8-diazaspiro[4,5]-decan-3-one were found to possess anti-ulcer activity comparable with that of omeprazole. © 2022, Springer Science+Business Media, LLC, part of Springer Nature.

Ivankin D.I. , Borisova M.S. , Sokolov D.N. , Luzina O.A. , Tolstikova T.G. , Salakhutdinov N.F.
Design, Synthesis, and Anti-Ulcer Activity of New 1-Thia-4,8-Diazaspiro[4,5]Decan-3-One Derivatives
Pharmaceutical Chemistry Journal. 2022. V.55. N12. P.1288-1292. DOI: 10.1007/s11094-022-02573-7 WOS Scopus

Web of science	WOS:000765036200004
Scopus	2-s2.0-85125678449
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