Abstract: Free fatty acid receptor-1 (FFAR1) is one of the possible therapeutic targets in the search for new hepatoprotective drugs. FFAR1 agonists were found to have hypolipidemic, antifibrotic, anti-inflammatory, antiproliferative and antioxidant effects in addition to hypoglycemic action. In this work, we conducted a study of the hepatoprotective effect of the compound QS-528 (previously discovered as an agonist of FFAR1) at doses of 60, 90, 120 and 150 mg/kg on carbon tetrachloride (CCl4 )-induced liver injury. At the end of the experiment, a biochemical blood assay demonstrated that the introduction of QS-528 dose-dependently reduces the levels of liver enzymes (AST, ALT and ALKP). Histological and morphometric studies of animals’ livers treated with QS-528 at doses of 120 and 150 mg/kg showed a decrease in degenerative/necrotic changes in hepatocytes and an increase in the regenerative activity of the liver. In addition, no toxicity at a single oral dose of 1000 mg/kg and an increase in HepG2 cell viability in vitro were found. Thus, the compound QS-528 was found to exhibit a hepatoprotective effect against CCl4 -induced toxic liver damage.

Cite: Pon`kina D. , Kuranov S. , Khvostov M. , Zhukova N. , Meshkova Y. , Marenina M. , Luzina O. , Tolstikova T. , Salakhutdinov N.
Hepatoprotective Effect of a New FFAR1 Agonist—N-Alkylated Isobornylamine
Molecules. 2023. V.28. N1. P.396. DOI: 10.3390/molecules28010396 WOS РИНЦ

Dates:

Submitted:	Dec 14, 2022
Published print:	Jan 3, 2023
Accepted:	Dec 29, 2023

Identifiers:

Web of science	WOS:000910154900001
Elibrary	60331791
OpenAlex	W4313432992

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