Click chemistry on diterpenes: anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations

Click chemistry on diterpenes: anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations Full article

Journal

ARKIVOC
ISSN: 1551-7004 , E-ISSN: 1551-7012

Output data

Year: 2014, Pages: 145-157 Pages count : 13 DOI: 10.3998/ark.5550190.p008.471

Tags

Acetylenes; Levopimaric acid; 1,2,3-triazole; Click Chemistry; diterpenoids; anti-inflammatory activity

Authors

Vasilevsky Sergey F. ^1,4 , Baranov Denis S. ¹ , Govdi Anastasia I. ¹ , Sorokina Irina V. ² , Tolstikova Tatyana G. ² , Tolstikov Genrikh A. ² , Alabugin Igor V. ³

Affiliations

1	(Данные Web of science) Russian Acad Sci, SB, VV Voevodsky Inst Chem Kinet & Combust, 3 Inst Skaya Str, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, SB, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
3	(Данные Web of science) Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA
4	(Данные Web of science) Instititute Novosibirsk State Univ, Novosibirsk 630090, Russia

Anti-inflammatory activity of amides of levopimaric acid (LpA) with acetylenic moiety and its esters with 4-R-triazolic substitutions was investigated using histamine-induced mice paw edema model. The synthesized LpA derivatives possess anti-inflammatory activity comparable to the activity of indomethacin.

Vasilevsky S.F. , Baranov D.S. , Govdi A.I. , Sorokina I.V. , Tolstikova T.G. , Tolstikov G.A. , Alabugin I.V.
Click chemistry on diterpenes: anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations

ARKIVOC. 2014. P.145-157. DOI: 10.3998/ark.5550190.p008.471 WOS Scopus РИНЦ

Full text from publisher

Published online:

Jul 19, 2014

Web of science	WOS:000345779400009
Scopus	2-s2.0-84905592935
Elibrary	23978895
OpenAlex	W2481008228