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Effect of 2-Aminoadamantane Derivatives on Behavior of Mice in a Modified Light/Dark Test Full article

Journal Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888
Output data Year: 2014, Volume: 158, Number: 2, Pages: 213-218 Pages count : 6 DOI: 10.1007/s10517-014-2725-4
Tags mice; 2-aminoadamantane; monoterpene; light/dark test; behavior
Authors Avgustinovich D.F. 1,2 , Fomina M.K. 3 , Suslov E.V. 3 , Tolstikova T.G. 3 , Volcho K.P. 3 , Salakhutdinov N.F. 3
Affiliations
1 (Данные Web of science) Russian Acad Sci, Siberian Div, Inst Cytol & Genet, Novosibirsk, Russia
2 (Данные Web of science) Russian Acad Med Sci, Res Inst Physiol & Fundamental Med, Siberian Div, Novosibirsk, Russia
3 (Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Moscow 117901, Russia

Abstract: The effects of two derivatives of 2-aminoadamantane, enantiomers J447H and J579, on the behavior of male and female C57Bl/6J mice were studied using a modified light/dark test. The substances differed by their effects on the behavior of male mice. J579 reduced the number of rearings. J447H in a dose of 1 mg/kg affected more parameters: it reduced exploratory activity 1 h after administration and stimulated exploratory and motor activity in 2 h. In female mice, J447H significantly reduced the number of peepings into holes in 2 h after administration. The results indicate that further analysis of the effects of J579 and especially J447H is required.
Cite: Avgustinovich D.F. , Fomina M.K. , Suslov E.V. , Tolstikova T.G. , Volcho K.P. , Salakhutdinov N.F.
Effect of 2-Aminoadamantane Derivatives on Behavior of Mice in a Modified Light/Dark Test
Bulletin of Experimental Biology and Medicine. 2014. V.158. N2. P.213-218. DOI: 10.1007/s10517-014-2725-4 WOS Scopus РИНЦ
ArticleLinkType.TRANSLATED_TO_ORIGINAL: Августинович Д.Ф. , Маренина М.К. , Суслов Е.В. , Толстикова Т.Г. , Волчо К.П. , Салахутдинов Н.Ф.
Исследование влияния производных 2-аминоадамантана на поведение мышей в модернизированном тесте "свет--темнота"
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2014. Т.158. №8. С.177-182. РИНЦ
Dates:
Published online: Nov 29, 2014
Published print: Dec 1, 2014
Identifiers:
Web of science WOS:000346635800010
Scopus 2-s2.0-84939933669
Elibrary 22775344
OpenAlex W1985214511
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