Meso-Aminomethyl-BODIPY as a Scaffold for Nitric Oxide Photo-Releasers

Meso-Aminomethyl-BODIPY as a Scaffold for Nitric Oxide Photo-Releasers Full article

Journal

ChemistrySelect
ISSN: 2365-6549

Output data

Year: 2023, Number: 8, Pages: 46 Pages count : 1 DOI: 10.1002/slct.202302681

Authors

Panfilov Mikhail A. ^1,2 , Karogodina Tatyana Yu. ^1,2 , Sibiryakova Anastasiya A. ¹ , Tretyakova Irina S. ^3,4 , Vorob'ev Alexey Yu. ^1,2 , Moskalensky Alexander E. ¹

Affiliations

1	Novosibirsk State University
2	N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
3	Voevodsky Institute of Chemical Kinetics and Combustion, SB RAS
4	Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences

Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Its short lifetime in physiological conditions and local action impede direct application in medicine because highly targeted NO-delivery systems are required. Light-controllable NO releasers are promising for the development of smart therapies. Here we present simply prepared meso-aminomethyl BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) derivatives containing N-nitroso moiety, which show the photoinduced generation of NO in a solution. These compounds can additionally generate singlet oxygen, and NO/1O2 generation efficiency can be tuned by substituents. As an example of NO-mediated effect, we demonstrate light-dependent inhibition of platelet activation in vitro. The presented compounds could serve as the basis for the development of novel hybrid therapeutic methods.

Panfilov M.A. , Karogodina T.Y. , Sibiryakova A.A. , Tretyakova I.S. , Vorob'ev A.Y. , Moskalensky A.E.
Meso-Aminomethyl-BODIPY as a Scaffold for Nitric Oxide Photo-Releasers
ChemistrySelect. 2023. N8. P.46. DOI: 10.1002/slct.202302681 WOS РИНЦ

Submitted:

Jul 7, 2023

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