Sciact
  • EN
  • RU

Solid-Effect Dynamic Nuclear Polarization in Viscous Liquids at 9.4 T Using Narrow-Line Polarizing Agents Full article

Journal Journal of the American Chemical Society
ISSN: 0002-7863
Output data Year: 2023, Volume: 145, Number: 18, Pages: 10268-10274 Pages count : 7 DOI: 10.1021/jacs.3c01358
Tags Alcohols, Electromagnetic radiation, Electron paramagnetic resonance spectroscopy, Magnetic properties, Polarization
Authors Kuzhelev Andrei A. 1 , Denysenkov Vasyl 1 , Ahmad Iram M. 2 , Rogozhnikova Olga Yu. 3 , Trukhin Dmitry V. 3 , Bagryanskaya Elena G. 3 , Tormyshev Victor M. 3 , Sigurdsson Snorri Th. 2 , Prisner Thomas F. 1
Affiliations
1 Institute of Physical and Theoretical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University Frankfurt am Main, Max von Laue Straße 7, 60438 Frankfurt am Main
2 University of Iceland
3 N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences

Funding (1)

1 Российский Научный Фонд 21-14-00219

Abstract: Dynamic nuclear polarization (DNP) is a hyperpolarization method that is widely used for increasing the sensitivity of nuclear magnetic resonance (NMR) experiments. DNP is efficient in solid-state and liquid-state NMR, but its implementation in the intermediate state, namely, viscous media, is still less explored. Here, we show that a 1H DNP enhancement of over 50 can be obtained in viscous liquids at a magnetic field of 9.4 T and a temperature of 315 K. This was accomplished by using narrow-line polarizing agents in glycerol, both the water-soluble α,γ-bisdiphenylen-β-phenylallyl (BDPA) and triarylmethyl radicals, and a microwave/RF double-resonance probehead. We observed DNP enhancements with a field profile indicative of the solid effect and investigated the influence of microwave power, temperature, and concentration on the 1H NMR results. To demonstrate potential applications of this new DNP approach for chemistry and biology, we show hyperpolarized 1H NMR spectra of tripeptides, triglycine, and glypromate, in glycerol-d8.
Cite: Kuzhelev A.A. , Denysenkov V. , Ahmad I.M. , Rogozhnikova O.Y. , Trukhin D.V. , Bagryanskaya E.G. , Tormyshev V.M. , Sigurdsson S.T. , Prisner T.F.
Solid-Effect Dynamic Nuclear Polarization in Viscous Liquids at 9.4 T Using Narrow-Line Polarizing Agents
Journal of the American Chemical Society. 2023. V.145. N18. P.10268-10274. DOI: 10.1021/jacs.3c01358 WOS Scopus РИНЦ
Dates:
Submitted: Feb 6, 2023
Published online: Apr 27, 2023
Published print: May 10, 2023
Identifiers:
Web of science WOS:000982196000001
Scopus 2-s2.0-85156184842
Elibrary 62269074
OpenAlex W4367173303
Altmetrics: