Synthesis new fluorinated 4-phenyl-1,4-dihydropyridine derivatives, as perspective antiarrhythmic and antihypertensive drugs Full article
| Journal |
Results in Chemistry
, E-ISSN: 2211-7156 |
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| Output data | Year: 2023, Volume: 5, Pages: 100705 Pages count : 1 DOI: 10.1016/j.rechem.2022.100705 | ||
| Tags | Sulfur-containing fluorinated 1,4-, dihydropyridines, Antiarrhythmic effect, Blood pressure | ||
| Authors |
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| Affiliations |
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Funding (1)
| 1 | Российский Научный Фонд | 22-73-00300 |
Abstract:
Derivatives of dihydropyridines are promising agents for research, as they have high biological activity. Their
low toxicity and polytargeted properties make it possible to create new derivatives and identify new biological
activity. As part of this work, we have obtained six new fluorinated derivatives of 4-phenyl-1,4-dihydropyridines.
These compounds were synthesized by a modified Hantzsch reaction, the interaction of polyfluorinated sulfurcontaining benzaldehydes with ethyl acetoacetate and ethyl 3-aminobut-2-enoate. Studies on the isolated
atrium have shown that the possible mechanism of action of the dihydropyridine derivatives lies in the blockade
of beta-adrenergic receptors. At the same time, it is not a blocker of potassium and calcium channels. The
fluorinated 4-phenyl-1,4-dihydropyridine derivatives, with SCF2H (decrease pressure) and SO2CH3 (increase
pressure) groups showed pronounced activity in the study of these derivatives on the blood pressure of rats.
Cite:
Bryzgalov A.
, Tolstikova T.
, Koshcheev B.
, Maksimov A.
Synthesis new fluorinated 4-phenyl-1,4-dihydropyridine derivatives, as perspective antiarrhythmic and antihypertensive drugs
Results in Chemistry. 2023. V.5. P.100705. DOI: 10.1016/j.rechem.2022.100705 WOS Scopus РИНЦ
Synthesis new fluorinated 4-phenyl-1,4-dihydropyridine derivatives, as perspective antiarrhythmic and antihypertensive drugs
Results in Chemistry. 2023. V.5. P.100705. DOI: 10.1016/j.rechem.2022.100705 WOS Scopus РИНЦ
Dates:
| Submitted: | Oct 17, 2023 |
| Accepted: | Dec 2, 2023 |
| Published online: | Dec 6, 2023 |
Identifiers:
| Web of science | WOS:000932748400008 |
| Scopus | 2-s2.0-85144025930 |
| Elibrary | 60316691 |
| OpenAlex | W4311757701 |