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Myrtenyl-bispidine containing azole: synthesis and antifungal activity Full article

Journal Mendeleev Communications
ISSN: 0959-9436
Output data Year: 2024, Volume: 34, Number: 1, Pages: 119-121 Pages count : 3 DOI: 10.1016/j.mencom.2024.01.036
Tags azoles, hybrids, Candida spp., bispidine, monoterpenes, myrtenol
Authors Li-Zhulanov Nikolai S. 1 , Ponomarev Konstantin Yu. 1 , Sari Suat 2 , Gülmez Dolunay 3 , Arikan-Akdagli Sevtap 3 , Krasnov Vyacheslav I. 1 , Suslov Evgenii V. 1 , Volcho Konstantin P. 1 , Salakhutdinov Nariman F. 1
Affiliations
1 N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russian Federation. E-mail: volcho@nioch.nsc.ru
2 Department of Pharmaceutical Chemistry, Hacettepe University Faculty of Pharmacy, Sihhiye, 06100 Ankara, Turkey
3 Department of Medical Microbiology, Hacettepe University Faculty of Medicine, Sihhiye, 06100 Ankara, Turkey

Funding (1)

1 Российский Научный Фонд 22-73-00046

Abstract: A new monoterpene–azole hybrid containing myrtenyl- bispidine moiety, 2-(2,4-difluorophenyl)-1-(7-{[(1R,5S)-6,6- dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl}-1,5-dimethyl- 3,7-diazabicyclo[3.3.1]non-3-yl)-3-(1H-1,2,4-triazol-1-yl)- propan-2-ol was prepared in six steps with 55% overall yield. The compound was tested against a number of Candida spp. fungi and found to be active against Candida albicans. Molecular docking suggested possible inhibition of lanosterol 14α-demethylase (CYP51), a membrane enzyme targeted by azole antifungals.
Cite: Li-Zhulanov N.S. , Ponomarev K.Y. , Sari S. , Gülmez D. , Arikan-Akdagli S. , Krasnov V.I. , Suslov E.V. , Volcho K.P. , Salakhutdinov N.F.
Myrtenyl-bispidine containing azole: synthesis and antifungal activity
Mendeleev Communications. 2024. V.34. N1. P.119-121. DOI: 10.1016/j.mencom.2024.01.036 WOS Scopus
Dates:
Submitted: Jul 18, 2023
Published online: Feb 8, 2024
Identifiers:
Web of science WOS:001182719500001
Scopus 2-s2.0-85184904293
OpenAlex W4391643456
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