The Study of Hypoglycemic Activity of 7-Terpenylcoumarins

The Study of Hypoglycemic Activity of 7-Terpenylcoumarins Full article

Journal

Molecules
, E-ISSN: 1420-3049

Output data

Year: 2022, Volume: 27, Number: 24, Pages: 8663 Pages count : 1 DOI: 10.3390/molecules27248663

Tags

terpene; coumarins; diabetes mellitus; hypoglycemic activity; OGTT; DPP IV

Authors

Kuranov Sergey ¹ , Marenina Mariya ¹ , Ivankin Dmitriy ¹ , Blokhin Mikhail ¹ , Borisov Sergey ¹ , Khomenko Tatyana ¹ , Luzina Olga ¹ , Khvostov Mikhail ¹ , Volcho Konstantin ¹ , Tolstikova Tatyana ¹ , Salakhutdinov Nariman ¹

Affiliations

1	N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences

Natural and synthetic coumarins are often considered privileged scaffolds for obtaining pharmacological agents with hypoglycemic activity. Chemical modification of coumarins often leads to antidiabetic agents with greater efficacy. In the present work, twenty monoterpene-substituted 7-hydroxycoumarins were synthesized. A new approach using the Mitsunobu reaction was shown to be effective for the synthesis of target compounds. All of the synthesized compounds were evaluated in an oral glucose tolerance test, and two of them containing geranyl and (-)-myrtenyl substituents showed in vivo hypoglycemic action. A possible mechanism of action of these compounds may include inhibition of DPP IV, which was proved in an in vitro test.

Kuranov S. , Marenina M. , Ivankin D. , Blokhin M. , Borisov S. , Khomenko T. , Luzina O. , Khvostov M. , Volcho K. , Tolstikova T. , Salakhutdinov N.
The Study of Hypoglycemic Activity of 7-Terpenylcoumarins
Molecules. 2022. V.27. N24. P.8663. DOI: 10.3390/molecules27248663 WOS РИНЦ

Submitted:	Oct 28, 2022
Accepted:	Dec 2, 2022
Published online:	Dec 7, 2022

Web of science	WOS:000903099700001
Elibrary	59506660
OpenAlex	W4311939289