Synthesis and Antibacterial Activity of Caffeine Derivatives Containing Amino-Acid Fragments

Synthesis and Antibacterial Activity of Caffeine Derivatives Containing Amino-Acid Fragments Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2022, Volume: 58, Number: 5, Pages: 908-915 Pages count : 8 DOI: 10.1007/s10600-022-03826-3

Tags

caffeine xanthines amino acids catalytic amination antibacterial activity

Authors

Reshetnikov D.V. ¹ , Burova L.G. ² , Rybalova T.V. ¹ , Bondareva E.A. ² , Patrushev S.S. ^1,3 , Evstropov A.N. ² , Shults E.E. ¹

Affiliations

1	N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
2	Новосибирский государственный медицинский университет
3	Novosibirsk State University

Cross-coupling of 8-bromocaffeine, 8-bromo-1-butyltheobromine, or 8-bromo-7-butyltheophylline with α-, β-, or ω-amino-acid methyl or t-butyl ester hydrochlorides in toluene in the presence of the catalytic system Pd(OAc)2·XantPhos and Cs2CO3 with microwave activation led to the formation of xanthine derivatives containing amino-acid fragments in the C-8 position. The antibacterial activity against Staphylococcus aureus and Bacillus cereus was studied.

Reshetnikov D.V. , Burova L.G. , Rybalova T.V. , Bondareva E.A. , Patrushev S.S. , Evstropov A.N. , Shults E.E.
Synthesis and Antibacterial Activity of Caffeine Derivatives Containing Amino-Acid Fragments
Chemistry of Natural Compounds. 2022. V.58. N5. P.908-915. DOI: 10.1007/s10600-022-03826-3 WOS РИНЦ

Submitted:	Apr 11, 2022
Published online:	Sep 24, 2022

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