Synthesis of berberine bromide analogs containing tertiary amides of acetic acid in the 9-O-position

Synthesis of berberine bromide analogs containing tertiary amides of acetic acid in the 9-O-position Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2013, Volume: 48, Number: 6, Pages: 1047-1053 Pages count : DOI: 10.1007/s10600-013-0461-z

Tags

berberine; berberine chloride; berberrubine; tertiary amides; isoquinoline alkaloids; hypocholesterolemic activity

Authors

Nechepurenko I. V. ¹ , Komarova N. I. ¹ , Vasil'ev V. G. ¹ , Salakhutdinov N. F. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, N N Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia

9-O-Acetamide analogs of berberine bromide were prepared in 20-87% yields via reaction of the isoquinoline alkaloid berberrubine with tertiary amides of bromoacetic acid. Aminolysis did not occur during reaction of methyl-2-(9-demethoxyberberine bromide-9-yl)hydroxyacetate with secondary amines. The corresponding acid or its ethyl ester was isolated.

Nechepurenko I.V. , Komarova N.I. , Vasil'ev V.G. , Salakhutdinov N.F.
Synthesis of berberine bromide analogs containing tertiary amides of acetic acid in the 9-O-position
Chemistry of Natural Compounds. 2013. V.48. N6. P.1047-1053. DOI: 10.1007/s10600-013-0461-z WOS Scopus РИНЦ

Published print:	Jan 1, 2013
Published online:	Feb 22, 2013

Web of science	WOS:000315417600033
Scopus	2-s2.0-84874403842
Elibrary	24941697
OpenAlex	W1967868005