Abstract: In view of the 2nd type diabetes mellitus “epidemic” developing over the world, and the absence of any efficient and safe drug therapy, the search for new hypoglycemic agents is a highly relevant task. Usnic acid produced by lichens, in addition to its diverse biological effects, also exhibits hypoglycemic action, though only in high doses. To decrease the effective hypoglycemic dose and reduce the risk of side effects, in the present work usnic acid was modified through reactions with the amino acid β-alanine and its derivatives. The hypoglycemic effect of the synthesized enamine derivatives of usnic acid was investigated in mice with alloxan-induced diabetes mellitus. It was determined that the derivative containing the amide fragment in the substituent exhibited a clearly pronounced hypoglycemic effect at the dose of 50 mg/kg. Neither of the studied compounds exhibited activity in the oral glucose-tolerance test in mice without any carbohydrate metabolism disorders.

Cite: BORISOV S.A. , LUZINA O.A. , KHVOSTOV M.V. , TOLSTIKOVA T.G. , SALAKHUTDINOV N.F.
Synthesis of the New Derivatives of Usnic Acid and Investigation of Their Hypoglycemic Properties
ХИМИЯ В ИНТЕРЕСАХ УСТОЙЧИВОГО РАЗВИТИЯ. 2022. V.30. N6. P.579-584. DOI: 10.15372/csd2022420 WOS РИНЦ

ArticleLinkType.TRANSLATED_TO_ORIGINAL: Борисов С.А. , Лузина О.А. , Хвостов М.В. , Толстикова Т.Г. , Салахутдинов Н.Ф.
Синтез новых производных усниновой кислоты и изучение их гипогликемических свойств
ХИМИЯ В ИНТЕРЕСАХ УСТОЙЧИВОГО РАЗВИТИЯ. 2022. №6. С.599-604. DOI: 10.15372/KhUR2022420 РИНЦ

Identifiers:

Web of science	WOS:000898661800001
Elibrary	49923486
OpenAlex	W4312360629

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