Synthesis and analgesic activity of alkyl-substituted octahydro-2H-chromenols Full article
| Journal |
Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171 |
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| Output data | Year: 2022, Volume: 71, Number: 11, Pages: 2482-2488 Pages count : 7 DOI: 10.1007/s11172-022-3677-x | ||
| Tags | monoterpenes montmorillonite K10 heterocyclic compounds analgesic activity | ||
| Authors |
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| Affiliations |
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Abstract:
A series of new compounds with hydrogenated 2H-chromene framework was synthesized starting from aliphatic aldehydes and available p-menthane monoterpenoid (−)-isopulegol in the presence of montmorillonite K10. These compounds were formed as a pair of diastereoisomers, which were isolated individually using column chromatography. Some of the compounds obtained were found to exhibit high analgesic activity in in vivo tests.
Cite:
Il’ina I.V.
, Korchagina D.V.
, Morozova E.A.
, Tolstikova T.G.
, Volcho K.P.
, Salakhutdinov N.F.
Synthesis and analgesic activity of alkyl-substituted octahydro-2H-chromenols
Russian Chemical Bulletin. 2022. V.71. N11. P.2482-2488. DOI: 10.1007/s11172-022-3677-x WOS РИНЦ
Synthesis and analgesic activity of alkyl-substituted octahydro-2H-chromenols
Russian Chemical Bulletin. 2022. V.71. N11. P.2482-2488. DOI: 10.1007/s11172-022-3677-x WOS РИНЦ
ArticleLinkType.TRANSLATED_TO_ORIGINAL:
Ильина И.В.
, Корчагина Д.В.
, Морозова Е.А.
, Толстикова Т.Г.
, Волчо К.П.
, Салахутдинов Н.Ф.
Синтез и изучение анальгетической активности алкилзамещенных октагидро-2H-хроменолов
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2022. №11. С.2482–2488.
Синтез и изучение анальгетической активности алкилзамещенных октагидро-2H-хроменолов
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2022. №11. С.2482–2488.
Dates:
| Submitted: | May 30, 2022 |
| Accepted: | Aug 30, 2022 |
| Published online: | Dec 19, 2022 |
Identifiers:
| Web of science | WOS:000921286500020 |
| Elibrary | 52057647 |
| OpenAlex | W4311944130 |