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Antitumor activity of amides of dihydrobetulonic acid in vitro and in vivo Full article

Journal Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620
Output data Year: 2013, Volume: 39, Number: 2, Pages: 194-201 Pages count : DOI: 10.1134/S106816201302012X
Tags dihydrobetulonic acid; amides; piperazine derivatives; antitumor activity; antimetastatic effect
Authors Sorokina I. V. 1 , Mainagashev I. Ya 1 , Zhukova N. A. 1 , Korchagina D. V. 1 , Tolstikova T. G. 1 , Nikolin V. P. 2 , Popova N. A. 2 , Pokrovskii M. A. 3 , Pokrovskii A. G. 3 , Salakhutdinov N. F. 1
Affiliations
1 (Данные Web of science) Russian Acad Sci, Vorozhtsov Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2 (Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia
3 (Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

Abstract: Amides containing homopiperidine and piperazine cycles were synthesized from dihydrobetulonic acid obtained by the oxidation of dihydrobetulin. All substances were shown to have a high antitumor activity (CCID50 = 3.5-36.2 mu M) in vitro in lymphoid (CEM-13, U-937) and monocytic (MT-4) human cell lines. Amides containing the methyl- and ethylpiperazine residues do not influence the viability of Lung Lewis Carcinoma cells in culture and do not have a significant effect on its transplants in C57BL/6 mice. However, these amides efficiently inhibit the development of metastases in lungs of these mice. The antimetastatic activity of the studied amides increases with changing the methyl by ethyl aliphatic residue in the piperazine cycle.
Cite: Sorokina I.V. , Mainagashev I.Y. , Zhukova N.A. , Korchagina D.V. , Tolstikova T.G. , Nikolin V.P. , Popova N.A. , Pokrovskii M.A. , Pokrovskii A.G. , Salakhutdinov N.F.
Antitumor activity of amides of dihydrobetulonic acid in vitro and in vivo
Russian Journal of Bioorganic Chemistry. 2013. V.39. N2. P.194-201. DOI: 10.1134/S106816201302012X WOS Scopus РИНЦ
Dates:
Published print: Mar 1, 2013
Published online: Mar 22, 2013
Identifiers:
Web of science WOS:000316686600011
Scopus 2-s2.0-84880717884
Elibrary 20446616
OpenAlex W2045066995
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