Crystalline products of tolbutamide decomposition in water after microwave treatment

Crystalline products of tolbutamide decomposition in water after microwave treatment Full article

Journal

CrystEngComm
ISSN: 1466-8033

Output data

Year: 2013, Volume: 15, Number: 18, Pages: 3582-3586 Pages count : DOI: 10.1039/c3ce40145f

Authors

Drebushchak Tatiana N. ^1,2 , Pankrushina Natalia A. ^1,3 , Mikheev Aleksandr N. ^1,4 , Thumm Manfred K. A. ¹

Affiliations

1	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
2	(Данные Web of science) Inst Solid State Chem & Mechanochem SB RAS, Novosibirsk, Russia
3	(Данные Web of science) Vorozhtsov Inst Organ Chem SB RAS, Novosibirsk, Russia
4	(Данные Web of science) Nikolaev Inst Inorgan Chem SB RAS, Novosibirsk, Russia

Microwave treatment of a hot water-drug suspension has resulted in the partial decomposition of tolbutamide (form I). Two new crystalline phases were isolated from the precipitate: the n-butylammoniun salt of tolbutamide and the novel polymorph of p-toluenesulfonamide. Their crystal structures were determined by single-crystal X-ray diffraction. The n-butylammoniun salt of tolbutamide is unstable in air and after decomposition crystallizes in the starting form I tolbutamide. The novel polymorph <beta > of p-toluenesulfonamide differs from the old one <alpha > in an unusual arrangement of layers.

Drebushchak T.N. , Pankrushina N.A. , Mikheev A.N. , Thumm M.K.A.
Crystalline products of tolbutamide decomposition in water after microwave treatment
CrystEngComm. 2013. V.15. N18. P.3582-3586. DOI: 10.1039/c3ce40145f WOS Scopus

Web of science	WOS:000317594600012
Scopus	2-s2.0-84879576416
OpenAlex	W2031724931