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Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09 Full article

Journal Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X
Output data Year: 2013, Volume: 10, Number: 6, Pages: 477-485 Pages count : DOI: 10.2174/1570180811310060002
Tags Adamantyamine; Antiviral; (H1N1)pdm09; Influenza; Monoterpenoid; Resistance
Authors Teplov George V. 1 , Suslov Evgeny V. 1 , Zarubaev Vladimir V. 2 , Shtro Anna A. 2 , Karpinskaya Liubov A. 2 , Rogachev Artem D. 1 , Korchagina Dina V. 1 , Volcho Konstantin P. 1 , Salakhutdinov Nariman F. 1 , Kiselev Oleg I. 2
Affiliations
1 (Данные Web of science) Russian Acad Sci, Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2 (Данные Web of science) Influenza Res Inst, Dept Chemotherapy, St Petersburg 197376, Russia

Abstract: A set of new nitrogen-containing compounds with adamantane and monoterpene frameworks was synthesized. The antiviral activity of the amine products against the influenza virus A/California/07/09 (H1N1)pdm09 was studied. The introduction of a monoterpenoid fragment led to increase of the antiviral activity of adamantylamine derivatives against adamantylamine resistant virus: the selectivity index of the majority of the synthesized amines was higher than that of rimantadine and amantadine.
Cite: Teplov G.V. , Suslov E.V. , Zarubaev V.V. , Shtro A.A. , Karpinskaya L.A. , Rogachev A.D. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F. , Kiselev O.I.
Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09
Letters in Drug Design and Discovery. 2013. V.10. N6. P.477-485. DOI: 10.2174/1570180811310060002 WOS Scopus РИНЦ
Dates:
Published print: May 1, 2013
Identifiers:
Web of science WOS:000318995000001
Scopus 2-s2.0-84879756004
Elibrary 20438885
OpenAlex W2321237620
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