3-Methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol: the Importance of Functional Groups for Antiparkinsonian Activity

3-Methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol: the Importance of Functional Groups for Antiparkinsonian Activity Full article

Journal

Medicinal Chemistry
ISSN: 1573-4064 , E-ISSN: 1875-6638

Output data

Year: 2013, Volume: 9, Number: 5, Pages: 731-739 Pages count : DOI: 10.2174/1573406411309050013

Tags

Antiparkinsonian activity; functional groups; (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol; mice; MPTP model

Authors

Ardashov Oleg V. ¹ , Pavlova Alla V. ¹ , Korchagina Dina V. ¹ , Volcho Konstantin P. ¹ , Tolstikova Tat'yana G. ¹ , Salakhutdinov Nariman F. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

Compounds with different sets of three of the four functional groups of (1R, 2R, 6S)-3-methyl-6-(prop-1-en-2yl) cyclohex-3-ene-1,2-diol 1 possessing high antiparkinsonian activity were synthesized. The synthesized compounds were tested for the antiparkinsonian activity in vivo on a mouse model with MPTP neurotoxin. A pronounced antiparkinsonian effect of 1 can only be achieved if it contains all the four functional groups (two hydroxy groups and two double bonds). The 2-hydroxy group or the 3,4-double bond is not required for stimulating the exploratory activity of the animals.

Ardashov O.V. , Pavlova A.V. , Korchagina D.V. , Volcho K.P. , Tolstikova T.G. , Salakhutdinov N.F.
3-Methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol: the Importance of Functional Groups for Antiparkinsonian Activity
Medicinal Chemistry. 2013. V.9. N5. P.731-739. DOI: 10.2174/1573406411309050013 WOS Scopus РИНЦ

Published print:

Jun 1, 2013

Web of science	WOS:000320326200012
Scopus	2-s2.0-84880684297
Elibrary	20445758
OpenAlex	W2165041743