Synthesis and study of mutagenic properties of lupane triterpenoids containing 1,2,3-triazole fragments in the C-30 position

Synthesis and study of mutagenic properties of lupane triterpenoids containing 1,2,3-triazole fragments in the C-30 position Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2013, Volume: 49, Number: 4, Pages: 657-664 Pages count : DOI: 10.1007/s10600-013-0702-1

Tags

betulin; betulinic acid; 1,2,3-triazoles; Cu-catalyzed 1,3-dipolar cycloaddition reaction; XSA; Ames test

Authors

Antimonova A. N. ¹ , Petrenko N. I. ¹ , Shakirov M. M. ¹ , Rybalova T. V. ¹ , Frolova T. S. ² , Shul'ts E. E. ¹ , Kukina T. P. ¹ , Sinitsyna O. I. ³ , Tolstikov G. A. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
3	(Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia

New derivatives of betulin, betulinic acid methyl ester, and their acetate analogs containing 1,2,3-triazole fragments in the C-30 position were synthesized. It was shown using the Ames test that 30-azidolup-20(29)-enes and 3 beta,28-diacetoxy-30-(4-R-1,2,3-triazol-1-yl)lup-20(29)-enes did not exhibit mutagenic properties.

Antimonova A.N. , Petrenko N.I. , Shakirov M.M. , Rybalova T.V. , Frolova T.S. , Shul'ts E.E. , Kukina T.P. , Sinitsyna O.I. , Tolstikov G.A.
Synthesis and study of mutagenic properties of lupane triterpenoids containing 1,2,3-triazole fragments in the C-30 position
Chemistry of Natural Compounds. 2013. V.49. N4. P.657-664. DOI: 10.1007/s10600-013-0702-1 WOS Scopus РИНЦ

Published print:	Sep 1, 2013
Published online:	Sep 20, 2013

Web of science	WOS:000324830200017
Scopus	2-s2.0-84885855301
Elibrary	21883136
OpenAlex	W2078377684