New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity

New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity Full article

Journal

Bioorganic and Medicinal Chemistry
ISSN: 0968-0896 , E-ISSN: 1464-3391

Output data

Year: 2013, Volume: 21, Number: 21, Pages: 6690-6698 Pages count : DOI: 10.1016/j.bmc.2013.08.014

Tags

Camphor; Imine derivatives; Antivirals; Influenza; Genotoxicity; Cytotoxicity

Authors

Sokolova Anastasiya S. ^1,2 , Yarovaya Olga I. ^1,2 , Shernyukov Andrey V. ¹ , Pokrovsky Michail A. ² , Pokrovsky Andrey G. ² , Lavrinenko Valentina A. ² , Zarubaev Vladimir V. ³ , Tretiak Tatiana S. ³ , Anfimov Pavel M. ³ , Kiselev Oleg I. ³ , Beklemishev Anatoly B. ⁴ , Salakhutdinov Nariman F. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
3	(Данные Web of science) All Union Influenza Res Inst, Dept Chemotherapy, St Petersburg 197376, Russia
4	(Данные Web of science) Russian Acad Med Sci, Siberian Branch, Res Inst Biochem, Novosibirsk 630117, Russia

The synthesis and biological evaluation of a novel series of dimeric camphor derivatives are described. The resulting compounds were studied for their antiviral activity, cyto- and genotoxicity. Compounds 3a and 3d in which the quaternary nitrogen atoms are separated by the C5H10 and C9H18 aliphatic chain, exhibited the highest efficiency as an agent inhibiting the reproduction of the influenza virus A(H1N1)pdm09. The cytotoxicity data of compounds 3 and 4 revealed their moderate activity against malignant cell lines; compound 3f had the highest activity for the CEM-13 cells. These results show close agreement with the data of independent studies on toxicity of these compounds, in particular that the toxicity of compounds strongly depends on spacer length. (C) 2013 Elsevier Ltd. All rights reserved.

Sokolova A.S. , Yarovaya O.I. , Shernyukov A.V. , Pokrovsky M.A. , Pokrovsky A.G. , Lavrinenko V.A. , Zarubaev V.V. , Tretiak T.S. , Anfimov P.M. , Kiselev O.I. , Beklemishev A.B. , Salakhutdinov N.F.
New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity

Bioorganic and Medicinal Chemistry. 2013. V.21. N21. P.6690-6698. DOI: 10.1016/j.bmc.2013.08.014 WOS Scopus РИНЦ

Full text from publisher

Published print:

Nov 1, 2013

Web of science	WOS:000325164500046
Scopus	2-s2.0-84885172779
Elibrary	21879792
OpenAlex	W2028560189