Simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging

Simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging Full article

Journal

Journal of Magnetic Resonance
ISSN: 1090-7807

Output data

Year: 2019, Volume: 305, Pages: 122-130 Pages count : DOI: 10.1016/j.jmr.2019.06.012

Tags

EPR; T-2* mapping; Nitroxyl radical; Single-point imaging; Gradient-descent optimization; Oxygenation

Authors

Yokoyama Takahito ¹ , Taguchi Akihiro ¹ , Kubota Harue ¹ , Stewart Neil J. ¹ , Matsumoto Shingo ¹ , Kirilyuk Igor A. ² , Hirata Hiroshi ¹

Affiliations

1	(Данные Web of science) Hokkaido Univ, Grad Sch Informat Sci & Technol, Div Bioengn & Bioinformat, Kita Ku, North 14,West 9, Sapporo, Hokkaido 0600814, Japan
2	(Данные Web of science) NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Ac Lavrentieva Ave, Novosibirsk 630090, Russia

This article reports a method of simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using 750-MHz continuous-wave electron paramagnetic resonance (CW-EPR) imaging. To separate the spectra of N-14- and N-15-labeled dicarboxy-PROXYLs under magnetic field gradients, an optimization problem for spectral projections was formulated with the spatial total variation as a regularization term and solved using a local search based on the gradient descent algorithm. Using the single-point imaging (SPI) method with spectral projections of each radical, simultaneous T-2* mapping was performed for solution samples. Simultaneous T-2* mapping enabled visualization of the response of T-2* values to the level of dissolved oxygen in the solution. Simultaneous T-2* mapping applied to a mouse tumor model demonstrated the feasibility of the reported method for potential application to in vivo oxygenation imaging. (C) 2019 Elsevier Inc. All rights reserved.

Yokoyama T. , Taguchi A. , Kubota H. , Stewart N.J. , Matsumoto S. , Kirilyuk I.A. , Hirata H.
Simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging

Journal of Magnetic Resonance. 2019. V.305. P.122-130. DOI: 10.1016/j.jmr.2019.06.012 WOS Scopus РИНЦ

Full text from publisher

Published print:

Aug 1, 2019

Web of science	WOS:000476468100017
Scopus	2-s2.0-85068190102
Elibrary	41650339
OpenAlex	W2953566413