Hepatoprotective activity of betulonic acid amides containing piperidine or pyrrolidine nitroxide moieties

Hepatoprotective activity of betulonic acid amides containing piperidine or pyrrolidine nitroxide moieties Full article

Journal

Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620

Output data

Year: 2013, Volume: 39, Number: 6, Pages: 668-670 Pages count : DOI: 10.1134/S1068162013060083

Tags

betulonic acid; nitroxyl radicals; antiholestatic effect; hepatoprotective activity

Authors

Sorokina I. V. ¹ , Baev D. S. ¹ , Zhukova N. A. ¹ , Tolstikova T. G. ¹ , Antimonova A. N. ¹ , Petrenko N. I. ¹ , Shults E. E. ¹ , Grigor'ev I. A. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

Betulonic acid amides containing the nitroxyl radical moiety exert an anticholestatic effect in mice. The introduction of piperidine nitroxide moiety into the lupane core increases its hepatoprotective activity. Oral administration of the piperidine nitroxide derivative in a dose of 50 mg/kg does not stimulate transplanted tumor growth and increases lifespan in mice.

Sorokina I.V. , Baev D.S. , Zhukova N.A. , Tolstikova T.G. , Antimonova A.N. , Petrenko N.I. , Shults E.E. , Grigor'ev I.A.
Hepatoprotective activity of betulonic acid amides containing piperidine or pyrrolidine nitroxide moieties
Russian Journal of Bioorganic Chemistry. 2013. V.39. N6. P.668-670. DOI: 10.1134/S1068162013060083 WOS Scopus РИНЦ

Published print:	Nov 1, 2013
Published online:	Nov 14, 2013

Web of science	WOS:000327091200011
Scopus	2-s2.0-84893133662
Elibrary	21909961
OpenAlex	W2063399253