Synthesis of 13-Aryl Derivatives of the Sesquiterpene Lactone Argolide and their Analgesic Activity

Synthesis of 13-Aryl Derivatives of the Sesquiterpene Lactone Argolide and their Analgesic Activity Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2013, Volume: 49, Number: 5, Pages: 875-881 Pages count : DOI: 10.1007/s10600-013-0768-9

Tags

sesquiterpene lactones; argolide; Heck reaction; x-ray crystal structure analysis; analgesic activity

Authors

Esenbaeva A. E. ¹ , Shul'ts E. E. ² , Gatilov Yu V. ² , Shakirov M. M. ² , Patrushev S. S. ² , Atazhanova G. A. ¹ , Kenesheva A. B. ¹ , Adekenov S. M. ¹

Affiliations

1	(Данные Web of science) Phytochemistry Corp, Karaganda 100009, Kazakhstan
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

13-Aryl-substituted derivatives of the germacranolide argolide were synthesized by a Heck reaction with arylhalides. The structure of (E)-13-(4-methoxyphenyl)-3-oxogermacra-1(10),11(13)-dien-6 alpha,12-olide was proved by an x-ray crystal structure analysis. Analgesic activity was found in the acetic-acid writhing test for the 13-arylgermacranolides.

Esenbaeva A.E. , Shul'ts E.E. , Gatilov Y.V. , Shakirov M.M. , Patrushev S.S. , Atazhanova G.A. , Kenesheva A.B. , Adekenov S.M.
Synthesis of 13-Aryl Derivatives of the Sesquiterpene Lactone Argolide and their Analgesic Activity
Chemistry of Natural Compounds. 2013. V.49. N5. P.875-881. DOI: 10.1007/s10600-013-0768-9 WOS Scopus РИНЦ

Published print:	Nov 1, 2013
Published online:	Nov 24, 2013

Web of science	WOS:000328199000020
Scopus	2-s2.0-84891039805
Elibrary	21902742
OpenAlex	W2004280583