Antioxidant activity of synthetic analogs and pure active principles of rhodiola rosea and raspberry ketone Full article
Journal |
Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031 |
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Output data | Year: 2012, Volume: 45, Number: 12, Pages: 732-735 Pages count : DOI: 10.1007/s11094-012-0713-4 | ||||
Tags | antioxidants; tyrosol; analogs; alpha-tocopherol; structure modification | ||||
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Abstract:
The antioxidant action of natural tyrosol derivatives, raspberry ketone, and their synthetic analogs was studied in comparison with alpha-tocopherol and butylhydroxytoluene. It is shown that hydroxylation of tyrosol increases the antioxidant activity 1.5 times. The introduction of one o-tert-butyl substituent increases the inhibiting action by a factor of 3.5; of two o-tert-butyl substituents, by greater than 4.0 times. The maximum inhibiting effect was observed for tert-butylhydroxytyrosol, the structural modification of which included simultaneously both hydroxylation and alkylation. The antioxidant activity of the studied substances was lower than that of alpha-tocopherol and butylhydroxytoluene. It was established that the induction periods of the studied antioxidants (AOs) in addition to many natural inhibitors (alpha-tocopherol, carotenoids, flavonoids) as functions of the concentrations of the studied AOs exhibit peaks. Thus, directed structural modifications of natural compounds yielded new effective oxidation inhibitors, the application of which will probably avoid undesired effects related to overdoses of the existing drugs.
Cite:
Storozhok N.M.
, Gureeva N.V.
, Khalitov R.A.
, Storozhok A.S.
, Krysin A.P.
Antioxidant activity of synthetic analogs and pure active principles of rhodiola rosea and raspberry ketone
Pharmaceutical Chemistry Journal. 2012. V.45. N12. P.732-735. DOI: 10.1007/s11094-012-0713-4 WOS Scopus РИНЦ
Antioxidant activity of synthetic analogs and pure active principles of rhodiola rosea and raspberry ketone
Pharmaceutical Chemistry Journal. 2012. V.45. N12. P.732-735. DOI: 10.1007/s11094-012-0713-4 WOS Scopus РИНЦ
Dates:
Published print: | Mar 1, 2012 |
Published online: | Apr 13, 2012 |
Identifiers:
Web of science | WOS:000303534900008 |
Scopus | 2-s2.0-85027956811 |
Elibrary | 41779885 |
OpenAlex | W2038260422 |