Synthetic transformations of sesquiterpene lactones. V.* Synthesis and cytotoxicity of 13-aryl-substituted tourneforin derivatives

Synthetic transformations of sesquiterpene lactones. V.* Synthesis and cytotoxicity of 13-aryl-substituted tourneforin derivatives Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2012, Volume: 48, Number: 2, Pages: 245-249 Pages count : 5 DOI: 10.1007/s10600-012-0214-4

Tags

tourneforin; Heck reaction; 13-aryleudesmanolides; tumor cells; XSA

Authors

Shul'ts E.E. ¹ , Patrushev S.S. ^1,2 , Belovodskii A.V. ¹ , Shakirov M.M. ¹ , Rybalova T.V. ¹ , Pokrovskii A.G. ² , Pokrovskii M.A. ² , Tolstikov G.A. ¹ , Adekenov S.M. ³

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
3	(Данные Web of science) Int Sci Prod Holding Fitokhimiya, Karaganda 100009, Kazakhstan

13-Aryl-substituted tourneforin derivatives were synthesized via the Heck reaction with aryliodides. The structure of (E)-13-(3,4-dimethoxybenzyl)-eudesma-4(5),11(13)-dien-6 alpha,12-olide was confirmed by an XSA. A study of the cytotoxicity of the synthesized derivatives for CEM-13, MT-4, and U-937 tumor models showed promise for the modification.

Shul'ts E.E. , Patrushev S.S. , Belovodskii A.V. , Shakirov M.M. , Rybalova T.V. , Pokrovskii A.G. , Pokrovskii M.A. , Tolstikov G.A. , Adekenov S.M.
Synthetic transformations of sesquiterpene lactones. V.* Synthesis and cytotoxicity of 13-aryl-substituted tourneforin derivatives
Chemistry of Natural Compounds. 2012. V.48. N2. P.245-249. DOI: 10.1007/s10600-012-0214-4 WOS Scopus РИНЦ

Published print:	May 1, 2012
Published online:	May 16, 2012

Web of science	WOS:000304651800017
Scopus	2-s2.0-85027919658
Elibrary	41777147
OpenAlex	W2028251223