Synthesis of 2,5-Bis(spirocyclohexane)-Substituted Nitroxides of Pyrroline and Pyrrolidine Series, Including Thiol-Specific Spin Label: An Analogue of MTSSL with Long Relaxation Time Full article
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Journal of Organic Chemistry
ISSN: 0022-3263 |
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Output data | Year: 2012, Volume: 77, Number: 18, Pages: 8016-8027 Pages count : DOI: 10.1021/jo301235j | ||||
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Abstract:
The nitroxides of 7-azadispiro[5.1.5.2]-pentadecane and 7-azadispiro[5.1.5.2]pentadeca-14-ene series have been prepared, including thiol-specific methane thiosulfonate spin label for site-directed spin labeling. The effect of spirocyclohexane moieties on chemical and spectral properties has been studied. The obtained temperature dependencies of electron spin relaxation parameters demonstrate that new nitroxides may be suitable for PELDOR distance measurements at 80-120 K. Moreover, the new nitroxides demonstrated much higher stability toward reduction by ascorbate than spirocyclohexane-substituted nitroxides of piperidine series and showed 1.3-3.14 times lower reduction rates compared to corresponding 2,2,5,5-tetramethyl nitroxides.
Cite:
Kirilyuk I.A.
, Polienko Y.F.
, Krumkacheva O.A.
, Strizhakov R.K.
, Gatilov Y.V.
, Grigor'ev I.A.
, Bagryanskaya E.G.
Synthesis of 2,5-Bis(spirocyclohexane)-Substituted Nitroxides of Pyrroline and Pyrrolidine Series, Including Thiol-Specific Spin Label: An Analogue of MTSSL with Long Relaxation Time
Journal of Organic Chemistry. 2012. V.77. N18. P.8016-8027. DOI: 10.1021/jo301235j WOS Scopus РИНЦ
Synthesis of 2,5-Bis(spirocyclohexane)-Substituted Nitroxides of Pyrroline and Pyrrolidine Series, Including Thiol-Specific Spin Label: An Analogue of MTSSL with Long Relaxation Time
Journal of Organic Chemistry. 2012. V.77. N18. P.8016-8027. DOI: 10.1021/jo301235j WOS Scopus РИНЦ
Dates:
Published online: | Sep 4, 2012 |
Published print: | Sep 21, 2012 |
Identifiers:
Web of science | WOS:000308957700024 |
Scopus | 2-s2.0-84867705933 |
Elibrary | 20496930 |
OpenAlex | W2328326144 |