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Influence of Usnic Acid and its Derivatives on the Activity of Mammalian Poly(ADP-ribose)polymerase 1 and DNA Polymerase beta Full article

Journal Medicinal Chemistry
ISSN: 1573-4064 , E-ISSN: 1875-6638
Output data Year: 2012, Volume: 8, Number: 5, Pages: 883-893 Pages count : DOI: 10.2174/157340612802084225
Tags DNA Polymerase beta; PARP1; Poly(ADP-ribose)polymerase; Usnic acid
Authors Zakharenko Alexandra 2 , Sokolov Dmitry 1 , Luzina Olga 1 , Sukhanova Maria 2 , Khodyreva Svetlana 2 , Zakharova Olga 2 , Salakhutdinov Nariman 1 , Lavrik Olga 2
Affiliations
1 (Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
2 (Данные Web of science) Russian Acad Sci, Siberian Branch, Novosibirsk Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia

Abstract: The influence of a number of usnic acid derivatives on auto(polyADP-ribosyl)ation catalyzed by PARP1 and DNA synthesis catalyzed by DNA polymerase beta was studied. The derivatives of usnic acid containing aromatic substituents were shown to be moderate inhibitors of PARP1. The presence of both usnic acid tricyclic structure and aromatic substituent at any position of the molecule is a key factor for the inhibitory action. In the case of DNA polymerase, no relationship between the structure and inhibitory properties has been found with the only exception. Derivatives with modified ring A showed mild activation of DNA synthesis catalyzed by DNA polymerase beta.
Cite: Zakharenko A. , Sokolov D. , Luzina O. , Sukhanova M. , Khodyreva S. , Zakharova O. , Salakhutdinov N. , Lavrik O.
Influence of Usnic Acid and its Derivatives on the Activity of Mammalian Poly(ADP-ribose)polymerase 1 and DNA Polymerase beta
Medicinal Chemistry. 2012. V.8. N5. P.883-893. DOI: 10.2174/157340612802084225 WOS Scopus РИНЦ
Dates:
Published print: Sep 1, 2012
Identifiers:
Web of science WOS:000309650400014
Scopus 2-s2.0-84865739563
Elibrary 20473542
OpenAlex W2314968626
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