Effect of Triterpene Derivatives on the Total Hepatocyte Count in the Liver of Rats with Toxic Hepatitis

Effect of Triterpene Derivatives on the Total Hepatocyte Count in the Liver of Rats with Toxic Hepatitis Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2012, Volume: 153, Number: 6, Pages: 859-862 Pages count : DOI: 10.1007/s10517-012-1844-z

Tags

toxic hepatitis; triterpene derivatives; heptral; biochemical markers; hepatocyte count

Authors

Semenov D. E. ¹ , Zhukova N. A. ² , Bessergeneva E. P. ² , Sorokina I. V. ² , Baev D. S. ² , Glukhov B. M. ¹ , Nepomnyaschikh G. I. ¹ , Tolstikova T. G. ²

Affiliations

1	(Данные Web of science) Russian Acad Med Sci, Res Inst Reg Pathol & Pathomorphol, Siberian Div, Novosibirsk, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Div, NN Vorozhtsov Inst Organ Chem, Novosibirsk, Russia

We studied hepatoprotective activity of betulonic acid and its alaninamide on the model of combined CCl4- and ethanol-induced toxic liver damage in rats. The test substances, especially betulonic acid alaninamide, considerably reduced the elevated biochemical parameters in animals with toxic liver damage. Betulonic acid alaninamide also stimulated reparative processes in the liver (activated hepatocyte proliferation). Heptral (reference drug) produced no appreciable effects on the reparative processes. Our findings suggest that betulin derivatives exhibit pronounced protective properties.

Semenov D.E. , Zhukova N.A. , Bessergeneva E.P. , Sorokina I.V. , Baev D.S. , Glukhov B.M. , Nepomnyaschikh G.I. , Tolstikova T.G.
Effect of Triterpene Derivatives on the Total Hepatocyte Count in the Liver of Rats with Toxic Hepatitis
Bulletin of Experimental Biology and Medicine. 2012. V.153. N6. P.859-862. DOI: 10.1007/s10517-012-1844-z WOS Scopus РИНЦ

Семенов Д.Е. , Жукова Н.А. , Бессергенева Е.П. , Сорокина И.В. , Баев Д.С. , Глухов Б.М. , Непомнящих Г.И. , Толстикова Т.Г.
Влияние тритерпеновых производных на общую численность гепатоцитов в печени крыс с токсическим гепатитом
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2012. Т.153. №6. С.837-840. РИНЦ

Published print:	Oct 1, 2012
Published online:	Nov 1, 2012

Web of science	WOS:000310811000014
Scopus	2-s2.0-84875586349
Elibrary	20482194
OpenAlex	W2022105583