Synthesis and Pro-Apoptotic Activity of Novel Glycyrrhetinic Acid Derivatives

Synthesis and Pro-Apoptotic Activity of Novel Glycyrrhetinic Acid Derivatives Full article

Journal

ChemBioChem
ISSN: 1439-4227 , E-ISSN: 1439-7633

Output data

Year: 2011, Volume: 12, Number: 5, Pages: 784-794 Pages count : 11 DOI: 10.1002/cbic.201000618

Tags

antitumor agents; apoptosis; biological activity; glycyrrhetinic acid derivatives; medicinal chemistry

Authors

Logashenko Evgeniya B. ¹ , Salomatina Oksana V. ² , Markov A.V. ¹ , Korchagina Dina V. ² , Salakhutdinov Nariman F. ² , Tolstikov Genrikh A. ² , Vlassov Valentin V. ¹ , Zenkova Marina A. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, Vorozhtsov Inst Organ Chem, Novosibirsk 630090, Russia

Triterpenoids are used for medicinal purposes in many countries. Some, such as oleanolic and glycyrrhetinic acids, are known to be anti-inflammatory and anticarcinogenic. However, the biological activities of these naturally occurring molecules against their particular targets are weak, so the synthesis of new synthetic analogues with enhanced potency is needed. By combining modifications to both the A and C rings of 18 beta H-glycyrrhetinic acid, the novel synthetic derivative methyl 2-cyano-3,12-dioxo-18bH-olean-9(11), 1(2)-dien-30-oate was obtained. This derivative displays high antiproliferative activity in cancer cells, including a cell line with a multidrug-resistance phenotype. It causes cell death by inducing the intrinsic caspase-dependent apoptotic pathway.

Logashenko E.B. , Salomatina O.V. , Markov A.V. , Korchagina D.V. , Salakhutdinov N.F. , Tolstikov G.A. , Vlassov V.V. , Zenkova M.A.
Synthesis and Pro-Apoptotic Activity of Novel Glycyrrhetinic Acid Derivatives

ChemBioChem. 2011. V.12. N5. P.784-794. DOI: 10.1002/cbic.201000618 WOS Scopus РИНЦ

Full text from publisher

Published online:	Feb 15, 2011
Published print:	Mar 21, 2011

Web of science	WOS:000288563000019
Scopus	2-s2.0-79952638583
Elibrary	16663570
OpenAlex	W2053131185