Calcium induced ATP synthesis: Isotope effect, magnetic parameters and mechanism

Calcium induced ATP synthesis: Isotope effect, magnetic parameters and mechanism Full article

Journal

Chemical Physics Letters
ISSN: 0009-2614 , E-ISSN: 1873-4448

Output data

Year: 2011, Volume: 505, Number: 4-6, Pages: 130-134 Pages count : 5 DOI: 10.1016/j.cplett.2011.02.036

Authors

Buchachenko A.L. ^1,2 , Kuznetsov D.A. ^1,3 , Breslavskaya N.N. ⁴ , Shchegoleva L.N. ⁵ , Arkhangelsky S.E. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Semenov Chem Phys Inst, Moscow 119991, Russia
2	(Данные Web of science) Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka 142432, Russia
3	(Данные Web of science) NI Pirogov Russian State Med Univ, Dept Med Nanobiotechnol, Moscow 117997, Russia
4	(Данные Web of science) Russian Acad Sci, NS Kurnakov Gen & Inorgan Chem Inst, Moscow 119991, Russia
5	(Данные Web of science) Russian Acad Sci, Siberian Dept, NN Vorozhtzov Inst Organ Chem, Novosibirsk 630090, Russia

ATP synthesis by creatine kinase with calcium ions is accompanied by Ca-43/Ca-40 isotope effect: the enzyme with Ca-43(2+) was found to be 2.0 +/- 0.3 times more active than enzymes, in which Ca2+ ions have nonmagnetic nuclei Ca-40. The effect demonstrates that primary reaction in ATP synthesis is electron transfer between reaction partners, Ca(H2O)(n)(2+) (n <= 3) and Ca2+(ADP)(3). It generates ion-radical pair, in which spin conversion results in the isotope effect. Magnetic parameters (g-factors and HFC constants a(Ca-43) and a(P-31)) confirm that namely terminal oxygen atom of the ADP ligand in the complex Ca2+(ADP)(3) donates electron to the Ca(H2O)(n)(2+) ion. (C) 2011 Elsevier B.V. All rights reserved.

Buchachenko A.L. , Kuznetsov D.A. , Breslavskaya N.N. , Shchegoleva L.N. , Arkhangelsky S.E.
Calcium induced ATP synthesis: Isotope effect, magnetic parameters and mechanism
Chemical Physics Letters. 2011. V.505. N4-6. P.130-134. DOI: 10.1016/j.cplett.2011.02.036 WOS Scopus РИНЦ

Published print:

Mar 1, 2011

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