Antiviral Activity of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol and its Derivatives Against Influenza A(H1N1)2009 Virus

Antiviral Activity of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol and its Derivatives Against Influenza A(H1N1)2009 Virus Full article

Journal

Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X

Output data

Year: 2011, Volume: 8, Number: 4, Pages: 375-380 Pages count : 6 DOI: 10.2174/157018011794839411

Tags

Monoterpenoids; para-menthane; Nicotinate; Influenza; Pandemic; Antiviral

Authors

Ardashov Oleg V. ¹ , Zarubaev Vladimir V. ² , Shtro Anna A. ² , Korchagina Dina V. ¹ , Volcho Konstantin P. ¹ , Salakhutdinov Nariman F. ¹ , Kiselev Oleg I. ²

Affiliations

1	Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russian Federation
2	Department of Chemotherapy, Influenza Research Institute, 15/17 Prof. Popova St., 197376 St. Petersburg, Russian Federation

A number of new derivatives of monoterpenoid with a para-menthane framework 3-methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol (-)-3 were synthesized. The antiviral activity of (-)-3 and its derivatives against the pandemic influenza virus A/California/07/09 (H1N1)v was studied in vitro. Compound (-)-3 was found to be active against this virus (selectivity index 7.5); for mononicotinate (+)-6 the selectivity index was 17. The absolute configuration of compound 6 was shown to be critical for its antiviral activity.

Ardashov O.V. , Zarubaev V.V. , Shtro A.A. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F. , Kiselev O.I.
Antiviral Activity of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol and its Derivatives Against Influenza A(H1N1)2009 Virus
Letters in Drug Design and Discovery. 2011. V.8. N4. P.375-380. DOI: 10.2174/157018011794839411 WOS Scopus РИНЦ

Published print:

May 1, 2011

Web of science	WOS:000290905200011
Scopus	2-s2.0-79955952679
Elibrary	16995543
OpenAlex	W2331197780