Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson's Disease

Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson's Disease Full article

Journal

Journal of Medicinal Chemistry
ISSN: 0022-2623

Output data

Year: 2011, Volume: 54, Number: 11, Pages: 3866-3874 Pages count : DOI: 10.1021/jm2001579

Authors

Ardashov Oleg V. ¹ , Pavlova Alla V. ¹ , Il'ina Irina V. ¹ , Morozova Ekaterina A. ¹ , Korchagina Dina V. ¹ , Karpova Elena V. ¹ , Volcho Konstantin P. ¹ , Tolstikova Tat'yana G. ¹ , Salakhutdinov Nariman F. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

(1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 possesses potent antiparkinsonian activity in both MPTP and haloperidol animal models. The use of compound 1 resulted in nearly full recovery of the locomotor and exploratory activities and was as effective as the comparator agent (levodopa). All eight stereoisomers of compound 1 have been synthesized and the influence of the absolute configuration on the antiparkinsonian activity of compound 1 was shown.

Ardashov O.V. , Pavlova A.V. , Il'ina I.V. , Morozova E.A. , Korchagina D.V. , Karpova E.V. , Volcho K.P. , Tolstikova T.G. , Salakhutdinov N.F.
Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson's Disease
Journal of Medicinal Chemistry. 2011. V.54. N11. P.3866-3874. DOI: 10.1021/jm2001579 WOS Scopus РИНЦ

Published print:

Jun 9, 2011

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