Sulfonium derivatives of thioxanthenone, a new class of photodetritylating agents for microarray oligonucleotide synthesis

Sulfonium derivatives of thioxanthenone, a new class of photodetritylating agents for microarray oligonucleotide synthesis Full article

Journal

Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620

Output data

Year: 2010, Volume: 36, Number: 1, Pages: 130-132 Pages count : DOI: 10.1134/S1068162010010152

Tags

photogenerators of acids; oligodeoxyribonucleotides; thioxanthenone; trityl cation

Authors

Sinyakov A. N. ¹ , Ryabinin A. A. ¹ , Maksakova G. A. ¹ , Shelkovnikov V. V. ² , Loskutov V. A. ² , Vasil'ev E. V. ² , Shekleina N. V. ²

Affiliations

1	(Данные Web of science) Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Organ Chem, Novosibirsk 630090, Russia

The usability of a new class of photo acids, namely, sulfonium hexaphosphates based on thioxanthenone, for the removal of the dimethoxytrityl protective group in the process of oligonucleotide synthesis has been studied in order to search for new detritylating agents for microarray oligodeoxyribonucleotide synthesis. 2,4-Diethyl-9-oxo-10-(4-heptyloxyphenyl)-9H-thioxanthenium hexafluorophosphate has been successfully used for the solid-phase synthesis of (dT)(10).

Sinyakov A.N. , Ryabinin A.A. , Maksakova G.A. , Shelkovnikov V.V. , Loskutov V.A. , Vasil'ev E.V. , Shekleina N.V.
Sulfonium derivatives of thioxanthenone, a new class of photodetritylating agents for microarray oligonucleotide synthesis
Russian Journal of Bioorganic Chemistry. 2010. V.36. N1. P.130-132. DOI: 10.1134/S1068162010010152 WOS Scopus РИНЦ

Синяков А.Н. , Рябинин А.А. , Максакова Г.А. , Шелковников В.В. , Лоскутов В.А. , Васильев Е.В. , Васильева Н.В.
Сульфониевые производные тиоксантенона новый класс соединений для фотодетритилирования в микрочиповом олигонуклеотидном синтезе
Биоорганическая химия (RUSS J BIOORG CHEM+). 2010. Т.31. №1. С.139-141. РИНЦ

Published print:	Jan 1, 2010
Published online:	Feb 2, 2010

Web of science	WOS:000274211500015
Scopus	2-s2.0-77649092151
Elibrary	15313256
OpenAlex	W2141938212