Antioxidative properties of nitroxyl radicals and hydroxyamines in reactions with triplet and deaminated kynurenine

Antioxidative properties of nitroxyl radicals and hydroxyamines in reactions with triplet and deaminated kynurenine Full article

Journal

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Output data

Year: 2010, Volume: 59, Number: 1, Pages: 66-74 Pages count : DOI: 10.1007/s11172-010-0046-y

Tags

kynurenine; 4-(2-aminophenyl)-4-oxocrotonic acid; triplet excited state; quenching reactions; laser flash photolysis; nitroxyl radicals; hydroxylamines

Authors

Yan'shole V. V. ¹ , Kirilyuk I. A. ² , Grigor'ev I. A. ^2,3 , Morozov S. V. ² , Tsentalovicha Yu. P. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Inst Int Tomog Ctr, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
3	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

The reactions of triplet kynurenine and 4-(2-aminophenyl)-4-oxocrotonic acid, formed upon the thermal decomposition of kynurenine, with nitroxyl radicals and cyclic N-hydroxylamines were studied. Nitroxyl radicals were found to quench efficiently the triplet state of kynurenine (rate constant 3-6 center dot.10(8) L mol(-1) s(-1)). The quenching proceeds via the spin-exchange mechanism and affords no new products. Neither nitroxyl radicals, nor hydroxyl-lamines react with 4-(2-aminophenyl)-4-oxocrotonic acid under conditions similar to physiological.

Yan'shole V.V. , Kirilyuk I.A. , Grigor'ev I.A. , Morozov S.V. , Tsentalovicha Y.P.
Antioxidative properties of nitroxyl radicals and hydroxyamines in reactions with triplet and deaminated kynurenine
Russian Chemical Bulletin. 2010. V.59. N1. P.66-74. DOI: 10.1007/s11172-010-0046-y WOS Scopus РИНЦ

Яньшоле В.В. , Кирилюк И.А. , Григорьев И.А. , Морозов С.В. , Центалович Ю.П.
Изучение антиоксидантных свойств нитроксильных радикалов и гидроксиламинов при взаимодействии с триплетным и дезаминированным кинуренином
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2010. №1. С.67. РИНЦ

Published print:	Jan 1, 2010
Published online:	Apr 19, 2010

Web of science	WOS:000277959600006
Scopus	2-s2.0-77955856339
Elibrary	15329241
OpenAlex	W2048882159