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Structural transformations of arabinogalactan from the Siberian larch during mechanochemical processing and the biological properties of the products Full article

Journal Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620
Output data Year: 2010, Volume: 36, Number: 7, Pages: 853-859 Pages count : DOI: 10.1134/S1068162010070101
Tags arabinogalactan from the Siberian larch; mechanochemical processing; gel-penetrating chromatography; molecular mass distribution; monosaccharide composition; quantitative C-13 NMR spectroscopy; toxicopharmacological studies
Authors Medvedeva E. N. 1 , Neverova N. A. 1 , Fedorova T. E. 1 , Babkin V. A. 1 , Meteleva E. S. 2 , Dushkin A. V. 2 , Tolstikova T. G. 3 , Khvostov M. V. 3 , Dolgikh M. P. 3
Affiliations
1 (Данные Web of science) Russian Acad Sci, Favorskii Inst Chem, Siberian Branch, Irkutsk 664033, Russia
2 (Данные Web of science) Russian Acad Sci, Inst Chem Solid Body & Mechanochem, Siberian Branch, Novosibirsk 630128, Russia
3 (Данные Web of science) Russian Acad Sci, Siberian Branch, Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia

Abstract: It has been found by gel-penetrating chromatography and quantitative C-13 NMR spectroscopy that mechanochemical processing of arabinogalactan isolated from the wood of the Siberian larch changes the molecular mass distribution, monosaccharide composition, and the degree of branching of its macromolecules. This is due to the partial destruction of polysaccharide macromolecules and subsequent recombination of resulting fragments. The intensity of these processes depends on the conditions of mechanochemical processing. Based on the data of IR and C-13 NMR spectra, the conclusion has been drawn that no functionalization of arabinogalactan macromolecules occurs under these conditions. The toxicopharmacological properties of mechanically processed arabinogalactan have been studied. Its acute toxicity is > 5000 mg/kg.
Cite: Medvedeva E.N. , Neverova N.A. , Fedorova T.E. , Babkin V.A. , Meteleva E.S. , Dushkin A.V. , Tolstikova T.G. , Khvostov M.V. , Dolgikh M.P.
Structural transformations of arabinogalactan from the Siberian larch during mechanochemical processing and the biological properties of the products
Russian Journal of Bioorganic Chemistry. 2010. V.36. N7. P.853-859. DOI: 10.1134/S1068162010070101 WOS Scopus РИНЦ
Dates:
Published online: Nov 26, 2010
Published print: Dec 1, 2010
Identifiers:
Web of science WOS:000284651100010
Scopus 2-s2.0-78649985829
Elibrary 16630314
OpenAlex W2094933057
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