Nitroxyl Antioxidant TPPA-TEMPO Increases the Efficacy of Antitumor Therapy on the Model of Transplantable Mouse Tumor

Nitroxyl Antioxidant TPPA-TEMPO Increases the Efficacy of Antitumor Therapy on the Model of Transplantable Mouse Tumor Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2010, Volume: 150, Number: 1, Pages: 75-78 Pages count : DOI: 10.1007/s10517-010-1073-2

Tags

LS lymphosarcoma; therapy; cyclophosphamide; nitroxyl radicals; TPPA-TEMPO

Authors

Kirilyuk I. A. ² , Kaledin V. I. ³ , Popova N. A. ³ , Nikolin V. P. ³ , Vasil'eva E. D. ³ , Grigor'ev I. A. ² , Lushnikova E. L. ¹ , Nepomnyashchikh L. M. ¹

Affiliations

1	(Данные Web of science) Russian Acad Med Sci, Siberian Div, Inst Reg Pathol & Pathomorphol, Novosibirsk, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Div, NN Vorozhtsov Novosibirsk Inst Organ Chem, Moscow 117901, Russia
3	(Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Div, Moscow 117901, Russia

Nitroxyl antioxidant 4-triphenylphosphonioacetamido-2,2,6,6-tetramethylpiperidine-1-oxyl (TPPA-TEMPO) was synthesized from 4-chloroacetamido-2,2,6,6-tetramethylpiperidine-1-oxyl chloride and triphenylphosphine. Systemic administration of TPPA-TEMPO in the subtoxic dose to mice with lymphosarcoma inhibited tumor growth, but did not prolong animal lifespan. Combined treatment with TPPA-TEMPO and cyclophosphamide increased the efficacy of antitumor therapy: it prolonged animal lifespan and increased the number of recovered mice.

Kirilyuk I.A. , Kaledin V.I. , Popova N.A. , Nikolin V.P. , Vasil'eva E.D. , Grigor'ev I.A. , Lushnikova E.L. , Nepomnyashchikh L.M.
Nitroxyl Antioxidant TPPA-TEMPO Increases the Efficacy of Antitumor Therapy on the Model of Transplantable Mouse Tumor
Bulletin of Experimental Biology and Medicine. 2010. V.150. N1. P.75-78. DOI: 10.1007/s10517-010-1073-2 WOS Scopus РИНЦ

Кирилюк И.А. , Каледин В.И. , Попова Н.А. , Николин В.П. , Васильева Е.Д. , Григорьев И.А. , Лушникова Е.Л. , Непомнящих Г.И.
Нитроксильный антиоксидант tppa-tempo повышает эффективность противоопухолевой терапии на модели перевиваемой лимфосаркомы мышей
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2010. Т.150. №7. С.85-89. РИНЦ

Published online:	Nov 25, 2010
Published print:	Dec 1, 2010

Web of science	WOS:000284906200022
Scopus	2-s2.0-79951637509
Elibrary	16635508
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