Structure of the Liver in Mice with Transplanted Lewis Carcinoma during Polychemotherapy and Correction with Betulonic Acid and Its Derivatives

Structure of the Liver in Mice with Transplanted Lewis Carcinoma during Polychemotherapy and Correction with Betulonic Acid and Its Derivatives Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2010, Volume: 150, Number: 1, Pages: 96-99 Pages count : DOI: 10.1007/s10517-010-1079-9

Tags

lung carcinoma; polychemotherapy; hepatotoxicity; betulonic acid and their derivatives; liver monphology

Authors

Zhukova N. A. ² , Sorokina I. V. ² , Tolstikova T. G. ² , Lushnikova E. L. ¹ , Nepomnyashih L. M. ¹ , Semenov D. E. ¹

Affiliations

1	(Данные Web of science) Russian Acad Med Sci, Res Inst Reg Pathol & Pathomorphol, Siberian Div, Novosibirsk, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Div, NN Vorozhtsov Inst Organ Chem, Novosibirsk, Russia

Morphological and morphometric studies of the liver with transplanted Lewis carcinoma were performed after polychemotherapy and correction with betulonic and [3-oxo-20(29)-lupene-28-oil]-3-aminopropionic acids and their methyl esters. It was demonstrated than betulonic and [3-oxo-20(29)-lupene-28-oil]-3-aminopropionic acids reduced the degree of degenerative changes and volume density of necrotic changes in hepatocytes after polychemotherapy. Methyl esters of these acids little changed the severity and spreading of destructive and necrotic changes in the liver caused by complex cytostatic therapy. It was also shown that all studied triterpenoids exhibited more pronounced antimetastatic effect (evaluated by the decrease in volume density of liver metastases) compared to polychemotherapy.

Zhukova N.A. , Sorokina I.V. , Tolstikova T.G. , Lushnikova E.L. , Nepomnyashih L.M. , Semenov D.E.
Structure of the Liver in Mice with Transplanted Lewis Carcinoma during Polychemotherapy and Correction with Betulonic Acid and Its Derivatives
Bulletin of Experimental Biology and Medicine. 2010. V.150. N1. P.96-99. DOI: 10.1007/s10517-010-1079-9 WOS Scopus РИНЦ

Жукова Н.А. , Сорокина И.В. , Толстикова Т.Г. , Лушникова Е.Л. , Непомнящих Г.И. , Семенов Д.Е.
Структура печени мышей с перевитой карциномой легких льюис при полихимиотерапии и коррекции бетулоновой кислотой и ее производными
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2010. Т.150. №7. С.108-112. РИНЦ

Published online:	Nov 25, 2010
Published print:	Dec 1, 2010

Web of science	WOS:000284906200028
Scopus	2-s2.0-79951628963
Elibrary	20527234
OpenAlex	W2026167079