Design of liposome-based pH sensitive nanoSPIN probes: nano-sized particles with incorporated nitroxides

Design of liposome-based pH sensitive nanoSPIN probes: nano-sized particles with incorporated nitroxides Full article

Journal

The Analyst
ISSN: 0003-2654 , E-ISSN: 1364-5528

Output data

Year: 2009, Volume: 134, Number: 5, Pages: 904-910 Pages count : DOI: 10.1039/b818184e

Authors

Woldman Yakov Y. ^1,3 , Semenov Sergey V. ^1,2 , Bobko Andrey A. ¹ , Kirilyuk Igor A. ⁴ , Polienko Julya F. ⁴ , Voinov Maxim A. ⁵ , Bagryanskaya Elena G. ² , Khramtsov Valery V. ¹

Affiliations

1	(Данные Web of science) Ohio State Univ, Med Ctr, Columbus, OH 43210 USA
2	(Данные Web of science) Int Tomog Ctr SB RAS, Novosibirsk 630090, Russia
3	(Данные Web of science) Valdosta State Univ, Valdosta, GA 31698 USA
4	(Данные Web of science) Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
5	(Данные Web of science) N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

Liposome-based nanoSized Particles with Incorporated Nitroxides, or nanoSPINs, were designed for EPR applications as pH probes in biological systems. Phospholipid membrane of the liposomes with incorporated gramicidin A showed selective permeability to a small analyte, H+, while protecting entrapped sensing nitroxide from biological reductants. An application of the pH-sensitive nanoSPIN in an ischemia model in rat heart homogenate allows for monitoring ischemia-induced acidosis while protecting encapsulated nitroxide against bioreduction.

Woldman Y.Y. , Semenov S.V. , Bobko A.A. , Kirilyuk I.A. , Polienko J.F. , Voinov M.A. , Bagryanskaya E.G. , Khramtsov V.V.
Design of liposome-based pH sensitive nanoSPIN probes: nano-sized particles with incorporated nitroxides

The Analyst. 2009. V.134. N5. P.904-910. DOI: 10.1039/b818184e WOS Scopus РИНЦ

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Web of science	WOS:000265355600014
Scopus	2-s2.0-65349120023
Elibrary	13613318
OpenAlex	W2082153374