Abstract: A series of amides based on (2S)-cyanopyrrolidine and alpha, beta-unsaturated aryl- and hetarylcarboxylic acids have been synthesized. The dependence of the hypoglycemic activity of compounds on the structure of the aromatic fragment has been studied in the oral glucose tolerance test in mice. Amides based on (E)-3-phenylprop-2-enoic and (E)-3-(4-methoxyphenyl)prop-2-enoic acids and (2S)-cyanopyrrolidine have been shown to significantly reduce blood glucose levels in mice. The observed hypoglycemic effect at a dose of 10 mg/kg is comparable to the effect of hypoglycemic drug vildagliptin.

Cite: Kuranov S.O. , Blokhin M.E. , Borisov S.A. , Khvostov M.V. , Luzina O.A. , Salakhutdinov N.F.
Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides
Russian Journal of Bioorganic Chemistry. 2019. V.45. N5. P.374-380. DOI: 10.1134/S1068162019050078 WOS Scopus РИНЦ

ArticleLinkType.TRANSLATED_TO_ORIGINAL: Куранов С.О. , Блохин М.Е. , Борисов С.А. , Хвостов М.В. , Лузина О.А. , Салахутдинов Н.Ф.
Синтез и гипогликемическая активность цианопирролидинамидов арил(гетарил)пропеновых кислот
Биоорганическая химия (RUSS J BIOORG CHEM+). 2019. Т.45. №5. С.534-541. РИНЦ

Dates:

Published print:	Sep 1, 2019
Published online:	Oct 17, 2019

Identifiers:

Web of science	WOS:000490947900008
Scopus	2-s2.0-85073608016
Elibrary	41691748
OpenAlex	W2980514780

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