Tempol reduces the therapeutic effect of cyclophosphamide on an experimental tumour model

Tempol reduces the therapeutic effect of cyclophosphamide on an experimental tumour model Full article

Journal

Free Radical Research
ISSN: 1071-5762

Output data

Year: 2009, Volume: 43, Number: 7, Article number : PII 912388525, Pages count : DOI: 10.1080/10715760902998198

Tags

Nitroxides; chemotherapy; cancer

Authors

Kaledin Vasily I. ² , Popova Nelly A. ² , Nikolin Valery P. ² , Vasilieva Evdokia D. ² , Kirilyuk Igor A. ¹ , Grigor'ev Igor A. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Novosibirsk 630090, Russia

The nitroxyl radical 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) is reported to elicite some effects on different biological models. This paper studied the influence of Tempol on the therapeutic action of an alkylating agent cyclophosphamide (CP) in the transplantable murine lymphosarcoma LS. When administered exactly before CP, Tempol exerted no influence on efficacy of the tumour therapy but significantly reduced it under a single or multiple preliminary injections 1-3 days before CP. This regimen of Tempol administration is found to elevate the activity of aldehyde dehydrogenase in the liver, the enzyme which is known to reduce the yield of the activated metabolite(s) of CP.

Kaledin V.I. , Popova N.A. , Nikolin V.P. , Vasilieva E.D. , Kirilyuk I.A. , Grigor'ev I.A.
Tempol reduces the therapeutic effect of cyclophosphamide on an experimental tumour model
Free Radical Research. 2009. V.43. N7. PII 912388525 . DOI: 10.1080/10715760902998198 WOS Scopus РИНЦ

Published print:	Jan 1, 2009
Published online:	Jul 21, 2009

Web of science	WOS:000266979200006
Scopus	2-s2.0-67650912074
Elibrary	13604928
OpenAlex	W2133085812