First stereoselective cyclisation in the cembrane series: X-ray structure of (+)-(4R,8R,11S,12E,14S,16R)-11-isopropyl-4,8,14-trimethyl-14-morpholin-4-yl-3-oxa-2-azatricyclo[6.6.2.0(4,16)]hexadeca-1,12-diene

First stereoselective cyclisation in the cembrane series: X-ray structure of (+)-(4R,8R,11S,12E,14S,16R)-11-isopropyl-4,8,14-trimethyl-14-morpholin-4-yl-3-oxa-2-azatricyclo[6.6.2.0(4,16)]hexadeca-1,12-diene Full article

Journal

Mendeleev Communications
ISSN: 0959-9436

Output data

Year: 2009, Volume: 19, Number: 5, Pages: 246-247 Pages count : DOI: 10.1016/j.mencom.2009.09.003

Authors

Agafontsev Alexander M. ¹ , Rybalova Tatyana V. ¹ , Gatilov Yurii V. ¹ , Tkachev Alexey V. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Dept Nat Sci, Novosibirsk 630090, Russia

A simple synthetic derivative of natural diterpene cembrene [(1S,2E,4S,7E, 11E)-4-morpholin-4-ylcembra-2,7,11-trien-5-one E-oxime] was found to be highly sensitive to acids (sulfuric and trifluoroacetic), and it is transformed under acidic conditions to a tricyclic bridged system with the 5,6-dihydro-4H-1,2-oxazine moiety.

Agafontsev A.M. , Rybalova T.V. , Gatilov Y.V. , Tkachev A.V.
First stereoselective cyclisation in the cembrane series: X-ray structure of (+)-(4R,8R,11S,12E,14S,16R)-11-isopropyl-4,8,14-trimethyl-14-morpholin-4-yl-3-oxa-2-azatricyclo[6.6.2.0(4,16)]hexadeca-1,12-diene
Mendeleev Communications. 2009. V.19. N5. P.246-247. DOI: 10.1016/j.mencom.2009.09.003 WOS Scopus РИНЦ

Published print:

Sep 1, 2009

Web of science	WOS:000271368800003
Scopus	2-s2.0-70349339516
Elibrary	15300097
OpenAlex	W2952304214