8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine: Novel Amino-benzopentathiepine having In Vivo Anticonvulsant and Anxiolytic Activities

8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine: Novel Amino-benzopentathiepine having In Vivo Anticonvulsant and Anxiolytic Activities Full article

Journal

Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X

Output data

Year: 2009, Volume: 6, Number: 6, Pages: 464-467 Pages count : DOI: 10.2174/157018009789057544

Tags

Substituted benzopentathiepins; Anticonvulsive activity; Anxiolytic activity

Authors

Khomenko Tatyana M. ¹ , Tolstikova Tatyana G. ¹ , Bolkunov Alexey V. ¹ , Dolgikh Margarita P. ¹ , Pavlova Alla V. ¹ , Korchagina Dina V. ¹ , Volcho Konstantin P. ¹ , Salakhutdinov Nariman F. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Novosibirsk Organ Chem Inst, Siberian Branch, Novosibirsk 630090, Russia

High anticonvulsive and anxiolytic activities of 8-trifluoromethyl-6-amino-benzopentathiepin 5, which can be synthesized by new simple and effective method, have been found. The transformation of the amino group in compound 5 to the amide group drastically changed the biological activity of the compounds.

Khomenko T.M. , Tolstikova T.G. , Bolkunov A.V. , Dolgikh M.P. , Pavlova A.V. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F.
8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine: Novel Amino-benzopentathiepine having In Vivo Anticonvulsant and Anxiolytic Activities
Letters in Drug Design and Discovery. 2009. V.6. N6. P.464-467. DOI: 10.2174/157018009789057544 WOS Scopus РИНЦ

Published print:

Sep 1, 2009

Web of science	WOS:000271392900010
Scopus	2-s2.0-69549092216
Elibrary	15310960
OpenAlex	W2152363260